LYTAK1 attenuates proliferation of retinal pigment epithelial cells through TGF- β-mediated epithelial-mesenchymal transition via the ERK/AKT signaling pathway.

In conclusion, these findings indicated that LYTAK1 may inhibit RPE cell proliferation through the TGF-β-mediated EMT/ERK/AKT signaling pathway, suggesting that TAK1 may be a potential target for the treatment of RPE diseases. PMID: 29201199 [PubMed]
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research