Dehydropropylpantothenamide isolated by a co-culture of Nocardia tenerifensis IFM 10554 T in the presence of animal cells

AbstractA new amide, named dehydropropylpantothenamide (1), was obtained by a co-culture ofNocardia tenerifensis IFM 10554T in the presence of the mouse macrophage-like cell line J774.1 in modified Czapek-Dox (mCD) medium. Compound1 was synthesized fromd-pantothenic acid calcium salt in 6 steps. The absolute configuration of natural compound1 was determined by comparisons of the optical rotation and CD spectra of synthetic1. In the present study, a new method for producing secondary metabolites was demonstrated using a “co-culture” in which the genusNocardia was cultured in the presence of an animal cell line.
Source: Journal of Natural Medicines - Category: Drugs & Pharmacology Source Type: research