What can palindromic rheumatism tell us?

Publication date: Available online 25 October 2017 Source:Best Practice & Research Clinical Rheumatology Author(s): Kulveer Mankia, Paul Emery Palindromic rheumatism (PR) is a syndrome characterised by recurrent, self-resolving inflammatory attacks in and around the joints. An association between PR and rheumatoid arthritis (RA) has long been postulated; a significant proportion of PR patients eventually develop RA and the majority also have anti-CCP antibodies. Therefore, PR is often considered a prodrome of RA. However, the clinical and imaging phenotype of PR has several important distinctions from RA. This suggests that despite the similarities, distinct disease mechanisms are at play. Given the paucity of evidence-based therapy in PR, a better understanding of these mechanisms will be important for refined and targeted therapeutic approaches for this important condition.
Source: Best Practice and Research Clinical Rheumatology - Category: Rheumatology Source Type: research