Dihydroartemisinin up-regulates VE-cadherin expression in human renal glomerular endothelial cells.

In this study, we found that DHA increased the expression of the junctional protein vascular endothelial (VE)-cadherin in human renal glomerular endothelial cells. In addition, DHA inhibited TGF-β RI-Smad2/3 signalling and its downstream effectors SNAIL and SLUG, which repress VE-cadherin gene transcription. Correspondingly, DHA decreased the binding of SNAIL and SLUG to the VE-cadherin promoter. Together, our results suggest an effect of DHA in regulating glomerular permeability by elevation of VE-cadherin expression.
PMID: 29193726 [PubMed - as supplied by publisher]

Source: J Cell Mol Med - November 29, 2017 Category: Molecular Biology Authors: Li L, Chen X, Dong F, Liu Q, Zhang C, Xu D, Allen TD, Liu J Tags: J Cell Mol Med Source Type: research