Nitric oxide and carbon monoxide antagonize TGF-β through ligand-independent internalization of TβR1/ALK5.

In this study primary cultures of VSMC from Sprague-Dawley rats were treated with NOR3 (a NO chemical donor), CORM2 (a CO chemical donor) or control. NO and CO stimulated dynamin-2 activation in VSMC. NO and CO promoted a time- and dose-dependent endocytosis of TβR1. By decreasing TβR1 surface expression through this dynamin-2 dependent process, NO and CO diminished the effects of TGF-β on VSMC. The findings help explain an important mechanism by which NO and CO signal in the vasculature by decreasing surface expression of the TβR1 and the cellular response to TGF-β. PMID: 25100282 [PubMed - as supplied by publisher]
Source: Am J Physiol Renal P... - Category: Urology & Nephrology Authors: Tags: Am J Physiol Renal Physiol Source Type: research

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Publication date: Available online 12 December 2019Source: Sensors and Actuators B: ChemicalAuthor(s): C. Pannek, T. Vetter, M. Oppmann, C. Weber, A. Eberhardt, M. Dold, M.-L. Bauersfeld, M. Henfling, S. Trupp, B. Schug, J. Wöllenstein, K. MandelAbstractFor early fire detection, the measurement of low and small rising concentrations of the fire typical gas carbon monoxide (CO) is essential. The approach presented herein integrates a highly sensitive colorimetric material into a low cost gas sensor system. The gas sensitive color dye is hosted by silica nanoparticle based supraparticles and then processed to a so-calle...
Source: Sensors and Actuators B: Chemical - Category: Chemistry Source Type: research
Authors: Shi S, Chen L, Qiu X, Zhao Q, Xiao Y, Yan X Abstract Objective: Several serum markers were reported to reflect the severity of pulmonary alveolar proteinosis (PAP). The aim of this study is to investigate a reliable and facile marker to access and monitor the clinical course of PAP in a large cohort. Methods: PAP patients from January 2010 to June 2018 were enrolled. Hospital records were used as data sources. The levels of various serum indicators were detected. We evaluated the correlation between pulmonary function test results and clinical variables. Results: Diffusion capacity for carbon monox...
Source: Disease Markers - Category: Laboratory Medicine Tags: Dis Markers Source Type: research
J. Mater. Chem. A, 2019, Advance Article DOI: 10.1039/C9TA12090D, PaperTianwei He, Karsten Reuter, Aijun Du Asymmetric copper and boron dual-site synergy for boosting conversion of carbon monoxide into value-added C2 products under visible light. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - J. Mater. Chem. latest articles - Category: Chemistry Authors: Source Type: research
Abstract Mixing ratios of atmospheric ammonia (NH3), nitric oxide (NO), carbon monoxide (CO), nonmethane hydrocarbons (NMHCs), and methane (CH4) were measured to investigate the vehicular emissions, which are a dominant source of atmospheric NH3 in urban sites of Delhi, India from January 2013 to December 2014. The annual average mixing ratios of NH3, NO, CO, NMHCs, and CH4 were 21.2 ± 2.1 ppb, 21.2 ± 6.1 ppb, 1.89 ± 0.18 ppm, 0.67 ± 0.21 ppm and 3.11 ± 0.53 ppm, respectively. Consideri...
Source: Archives of Environmental Contamination and Toxicology - Category: Environmental Health Authors: Tags: Arch Environ Contam Toxicol Source Type: research
Condition:   Liver Cancer Interventions:   Procedure: CO Testing Pre/Post Hepatic Resection;   Diagnostic Test: ABG Testing Pre/Post Hepatic Resection;   Diagnostic Test: CT Evaluations Sponsor:   University of Maryland, Baltimore Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
The Journal of Organic ChemistryDOI: 10.1021/acs.joc.9b02575
Source: The Journal of Organic Chemistry - Category: Chemistry Authors: Source Type: research
This article is licensed under aCreative Commons Attribution-NonCommercial 3.0 Unported Licence.Matthias Driess, Shenglai Yao, Yun Xiong, Tibor Szilvasi, Ale š Růžička The unexpected reactivity of the o-carborane supported bis-silylene [(LSi:)C]2B10H10 1 {L= PhC(tBuN)2} towards carbon monoxide and 2,6-dimethylphenyl isocyanide is reported. While the reaction of 1 with CO leads selectively to... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - Category: Chemistry Authors: Source Type: research
; TRS Abstract Carbon monoxide (CO), an endogenously produced gasotransmitter, regulates inflammation and vascular tone, suggesting delivery of CO may be therapeutically useful for pathologies like preeclampsia where CO insufficiency are implicated. Our strategy is to identify chemicals that increase the activity of endogenous CO producing enzymes, including cytochrome P-450 oxidoreductase (CPR). Realizing both riboflavin and pyrroloquinoline quinone (PQQ) are relatively non-toxic, even at high doses, and they share chemical properties with toxic CO activators we previously identified, our goal was to determine wh...
Source: Canadian Journal of Physiology and Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Can J Physiol Pharmacol Source Type: research
ConclusionThe DLCO% and MLD may predict the risk for SARP among patients with pre-treatment moderate pulmonary dysfunction who receive dCCRT for NSCLC. Prospective studies are needed to validate our findings.
Source: Strahlentherapie und Onkologie - Category: Cancer & Oncology Source Type: research
This patient was working on his truck in a garage without ventilation and the vehicle was running. He felt dizzy and lost consciousness. The next thing he remembers is waking up in the ambulance. He was last seen normal at 09:00 AM and was found down at 10:30 AM. He denied chest pain, abdominal pain, SOB or any other symptoms, though he did endorse chest pressure when asked specifically.He underwent a routine ECG prior to hyperbaric therapy for CO poisoning:Obvious Massive STEMI, Proximal LAD OcclusionHis CO level returned at 34%.Further h/o revealed that he had had a proximal LAD stent placed for a Non-Occlusion MI more t...
Source: Dr. Smith's ECG Blog - Category: Cardiology Authors: Source Type: blogs
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