Nitric oxide and carbon monoxide antagonize TGF-β through ligand-independent internalization of TβR1/ALK5.

In this study primary cultures of VSMC from Sprague-Dawley rats were treated with NOR3 (a NO chemical donor), CORM2 (a CO chemical donor) or control. NO and CO stimulated dynamin-2 activation in VSMC. NO and CO promoted a time- and dose-dependent endocytosis of TβR1. By decreasing TβR1 surface expression through this dynamin-2 dependent process, NO and CO diminished the effects of TGF-β on VSMC. The findings help explain an important mechanism by which NO and CO signal in the vasculature by decreasing surface expression of the TβR1 and the cellular response to TGF-β. PMID: 25100282 [PubMed - as supplied by publisher]
Source: Am J Physiol Renal P... - Category: Urology & Nephrology Authors: Tags: Am J Physiol Renal Physiol Source Type: research