Woman With Transplanted Uterus Gives Birth, the First in the U.S.

A woman born without a uterus had one transplanted from a live donor, and gave birth to a healthy son, at Baylor University Medical Center in Dallas.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Transplants Uterus Baylor University Baby Pregnancy and Childbirth Infertility Cleveland Clinic Source Type: news

Related Links:

Purpose of review The current review gives an updated synopsis of all cases of uterus transplantation (UTx) that has been published and technical details about surgery. The live births that so far have been reported are described regarding pregnancy and outcome. In addition, the review highlights some specific areas of live donor UTx, deceased donor UTx and UTx in general that need further research for clarification/optimization. It is predicted that the clinical field of UTx will expand rapidly and recommendations for a scientific development of the UTx field are presented. Recent findings The first successful UTx wa...
Source: Current Opinion in Organ Transplantation - Category: Surgery Tags: COMPOSITE TISSUE TRANSPLANTATION: Edited by Gerald Brandacher Source Type: research
The decidua is a transient uterine tissue shared by mammals with hemochorial placenta and is essential for pregnancy. Hoxa11 knockout (KO) mice are infertile having endometrial stromal cell defects resulting in lack of decidualization and implantation failure. Since bone marrow (BM)-derived cells (BMDC) were shown to differentiate into non-hematopoietic endometrial cells, we hypothesized that bone marrow transplantation from wild-type (WT) mice may rescue uterine defects in Hoxa11 KO mice.
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Oral session Source Type: research
uml;m M Abstract PURPOSE OF REVIEW: The current review gives an updated synopsis of all cases of uterus transplantation (UTx) that has been published and technical details about surgery. The live births that so far have been reported are described regarding pregnancy and outcome. In addition, the review highlights some specific areas of live donor UTx, deceased donor UTx and UTx in general that need further research for clarification/optimization. It is predicted that the clinical field of UTx will expand rapidly and recommendations for a scientific development of the UTx field are presented. RECENT FINDINGS:...
Source: Current Opinion in Organ Transplantation - Category: Transplant Surgery Authors: Tags: Curr Opin Organ Transplant Source Type: research
There is rapidly growing interest in uterine transplantation for the management of uterine factor infertility (UFI). Recent experimental procedures have demonstrated that women with congenital or acquired absence of a uterus can become pregnant and give birth to a child after a successful uterine transplant, with the first birth occurring in 2015 [1]. The procedure was once considered only in theory, remaining a unique intersection of reproductive and transplant medicine that had never been undertaken.
Source: The Journal of Minimally Invasive Gynecology - Category: OBGYN Authors: Tags: Editorial Source Type: research
To regenerate functional endometrium tissue using “cell sheet” techniques as a regenerative medicine approach to address endometrial disorders causing female factor infertility.
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Original article Source Type: research
Abstract Severe uterine damage and infection lead to intrauterine adhesions, which result in hypomenorrhea, amenorrhea and infertility. Cell sheet engineering has shown great promise in clinical applications. Adipose-derived stem cells (ADSCs) are emerging as an alternative source of stem cells for cell-based therapies. In the present study, we investigated the feasibility of applying ADSCs as seed cells to form scaffold-free cell sheet. Data showed that ADSC sheets expressed higher levels of FGF, Col I, TGFβ and VEGF than ADSCs in suspension, while increased expression of this gene set was associated with st...
Source: Biology of Reproduction - Category: Reproduction Medicine Authors: Tags: Biol Reprod Source Type: research
Purpose of review The purpose of this review is to analyze what is known to date about the relation between telomeres and male fertility, and if it is possible for telomeres, or elements related to them, to be used as new prognostic biomarkers in fertility treatment. Recent findings Cells in germ series, including spermatozoids, have longer telomeres (10–20 kb), and do not seem to undergo the shortening that takes place in somatic cells with age as they present telomerase activity. Longer telomere length found in the sperm of older fathers, influences their offspring possessing cells with longer telomere length....
Source: Current Opinion in Obstetrics and Gynecology - Category: OBGYN Tags: FERTILITY, IVF AND REPRODUCTIVE GENETICS: Edited by Emre Seli and Juan A. García-Velasco Source Type: research
Dr. Giuliano Testa, a transplant surgeon at Baylor University Medical Center at Dallas who led the medical team that performed the first successful uterus transplants in the United States, said Tuesday that he hopes “what we are doing is going to shed light on infertility for women.” “I personally never knew it was such a widespread issue,” Testa said at the TIME 100 Gala on Tuesday. “We should be thinking about it not just as a birth, but a wellbeing issue.” Testa attended the TIME 100 Gala after being named by TIME magazine as one of the most influential people in the world for his rol...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized onetime T1002018 Source Type: news
Although cancer remains a critical health concern, significant medical advances in cancer detection and treatment have improved survival rates for patients. In children receiving total body radiation (TBI), bone-marrow transplant (BMT), or cyclophosphamide equivalent dose (CED) of>4,000mg/m2, the risk of infertility is significant. The National Physicians Cooperative (NPC) has published site-specific articles compiling data regarding use of cryopreserved tissue, return of endocrine function, and pregnancy outcomes, however no comprehensive review has been conducted.
Source: Journal of Pediatric and Adolescent Gynecology - Category: OBGYN Authors: Source Type: research
This study presents a summary of the investigations that indicate the key role of stem cell therapy in regeneration and renovation of defective parts.
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
More News: Babies | Health | Infertility | Pregnancy | Reproduction Medicine | Transplants