Hepatoblastoma in an extremely low birth-weight infant with Beckwith –Wiedemann syndrome

Beckwith –Wiedemann syndrome (BWS) (OMIM 130650) is a congenital overgrowth disorder accompanied by macroglossia, umbilical hernia, organomegaly, and neonatal hypoglycemia.1,2 BWS predisposes the affected individuals to embryonic tumors (e.g., Wilms tumor, hepatoblastoma, and neuroblastoma) and is caused b y several types of molecular abnormalities that can be genomic or epigenetic. It has been recently demonstrated that the risk of tumor development appears to be dependent on these molecular subtypes.
Source: Pediatrics and Neonatology - Category: Perinatology & Neonatology Authors: Tags: Short Communication Source Type: research