Metals and Parkinson's disease: Mechanisms and biochemical processes.

Metals and Parkinson's disease: Mechanisms and biochemical processes. Curr Med Chem. 2017 Nov 29;: Authors: Bjørklund G, Stejskal V, Urbina MA, Dadar M, Chirumbolo S, Mutter J Abstract Genetic background accounts for only 5 to 10% of the reported cases of Parkinson's disease (PD), while the remaining cases are of unknown etiology. It is believed that environmental factors may be involved in the causality of a large proportion of PD cases. Several PD genes are activated by xenobiotic exposure, and a link between pesticide exposure and PD has been demonstrated. Many epidemiological studies have shown an association between PD and exposure to metals such as mercury, lead, manganese, copper, iron, aluminum, bismuth, thallium, and zinc. This review explores the biological effects, the pathogenetic processes, genetic susceptibilities to metals as well as examining future strategies for PD treatment, such as chelation therapy. PMID: 29189118 [PubMed - as supplied by publisher]
Source: Current Medicinal Chemistry - Category: Chemistry Authors: Tags: Curr Med Chem Source Type: research