The Development of Biologically Important Spirooxindoles as New Antimicrobial Agents.

The Development of Biologically Important Spirooxindoles as New Antimicrobial Agents.
Curr Med Chem. 2017 Nov 29;:
Authors: Yang YT, Zhu JF, Liao G, Xu HJ, Yu B
Abstract
Spirooxindoles are privileged scaffolds because of their prevalence in numerous biologically validated natural alkaloids and pharmaceutically relevant molecules. In last decades, a large number of structurally novel spirooxindoles have been synthesized mainly based on the ylide intermediates generated in situ and further assessed for their bioactivities. While the antimicrobial activity against different types of bacteria is relatively less studied, mainly centering on primary antimicrobial assessment, some of these compounds have showed interesting antimicrobial activity, comparable to that of antibiotics used in clinic.
PMID: 29189121 [PubMed - as supplied by publisher]

Source: Current Medicinal Chemistry - November 29, 2017 Category: Chemistry Authors: Yang YT, Zhu JF, Liao G, Xu HJ, Yu B Tags: Curr Med Chem Source Type: research