Mozart's music in children with drug-refractory epileptic encephalopathies: Comparison of two protocols.
In conclusion, the present study seems to confirm that music therapy may be an additional, nonpharmacological, effective treatment for patients with refractory epileptic seizures in childhood. The Mozart's set of different compositions can be better accepted and effective than the K448. PMID: 29182948 [PubMed - as supplied by publisher]
Narcolepsy is characterized by excessive sleepiness, hypnagogic hallucinations, and sleep paralysis, and can occur with or without cataplexy. Here, we report two children with narcolepsy presenting with cataplexy mimicking epileptic seizures as determined by long-term video-electroencephalography (EEG) and electromyography (EMG) monitoring.Case 1 was a 15-year-old girl presenting with recurrent episodes of “convulsions” and loss of consciousness, who was referred to our hospital with a diagnosis of epilepsy showing “convulsions” and “complex partial seizures”.
Sleep and epilepsy have a dynamic reciprocal relationship. Epileptiform discharges are more common in sleep (Malow et al. 1998) and the occurrence of seizures depends on sleep stage (Minecan et al. 2002). We had previously shown that the amount of sleep spindles is reduced before epileptic seizures (Tezer et al. 2014). To understand the time dynamic of this process, we now investigated how long before the seizure this reduction begins.
Abstract PURPOSE OF REVIEW: The purpose of this review was to discuss the currently available pharmacologic and non-pharmacologic treatment options for parasomnias. RECENT FINDINGS: Recent pathophysiological findings about sleep structure in parasomnias helped understanding several drug mechanisms of action. Serotoninergic theory accounts for the effect of serotoninergic drugs. Study about spectral analysis of sleep showed the effect of clonazepam on spectral bands. Cannabinoids proved to be effective in some of parasomnias, as in many other neurological disorders. A series of therapeutic strategies were anal...
Abstract Post-traumatic epilepsy is the architype of acquired epilepsies, wherein a brain insult initiates an epileptogenic process culminating in an unprovoked seizure after weeks, months or years. Identifying biomarkers of such process is a prerequisite for developing and implementing targeted therapies aimed at preventing the development of epilepsy. Currently, there are no validated electrophysiological biomarkers of post-traumatic epileptogenesis. Experimental EEG studies using the lateral fluid percussion injury model have identified three candidate biomarkers of post-traumatic epileptogenesis: pathological ...
A routine or standard Electroencephalography (EEG) study is frequently requested by paediatricians to aid diagnosis of epilepsy in children presenting with episodic behaviours. EEG study in children is significantly more sensitive if it includes a period of sleep. It is a valuable investigation provided it is considered in the context of good clinical history and interpreted with familiarity of the range of episodic behaviours in childhood, and the prevalence of incidental epileptiform abnormalities in children with or without neurodevelopmental abnormalities.
Abstract Sleep is a dynamic process, during which the electrical rhythms of the brain orchestrate a complicated progression of changing frequencies, patterns and connectivity. Each stage of sleep is different electrophysiologically from wakefulness, and from other sleep stages. It should be no surprise, then, that the various sleep states influence the origin, suppression, and spread of seizures, and that different seizure types are affected in individual (and sometimes contradictory) ways. While much of the electrical symphony that occurs in both normal and epileptic brains is incompletely understood, at the basi...
CONCLUSION: Considering the high diagnostic yield of an awake and asleep EEG monitoring, as it was observed in the current study, this test on a screening basis can be reasonably justified in all children with developmental disabilities. PMID: 29758444 [PubMed - as supplied by publisher]
CONCLUSIONS: This study suggests that amantadine may be effective in the treatment of ESES-associated syndromes but warrants replication in a more rigorous study. PMID: 29754107 [PubMed - as supplied by publisher]
The aim of this study was to characterize the neuropsychological features of a representative sample of sleep-related hypermotor epilepsy (SHE) patients and to highlight clinical associations.