Evaluation of Mir-224, Mir-215 and Mir-143 as Serum Biomarkers for HCV Associated Hepatocellular Carcinoma
This study was performed to estimate the level of these miRNAs in serum of
patients with HCV-associated hepatitis and HCC in relation to grade of hepatitis, stage of fibrosis and differentiation of
tumor tissue. In addition, correlations between serological and tissue levels were assessed. A total of 80 patients were
examined, out of which 50 were included in the study. Blood samples and tissue specimens from malignant tumor and
corresponding non-tumor tissue of HCV hepatitis patients were collected. Blood samples from 20 healthy volunteers
were also obtained as controls. It was found that miRNAs profiles differed in HCC patients compared to controls and
HCV-associated hepatitis cases. Distinction of tumor grade and fibrosis stage of patients as well as between different
grades of tumor differentiation proved possible, making miRNAs promising biomarkers for diagnosis and assessment
of treatment response of HCC patients.
PMID: 29172295 [PubMed]
Source: Asian Pacific Journal of Cancer Prevention - Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research
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