A devices ’ game of thrones: cardiac resynchronization therapy vs. pacemaker

ConclusionThis paper emphasizes the importance of knowing the distinct pacemaker brady mode behaviours after battery capacity depleted indicator has been reached, according to the pacemakers ’ manufacturer, including the possibility of automatic brady mode change from sensing to pacing mode. It also highlights the potential for severe bradycardia or asystole of this automatic brady mode change from a previously implanted pacemaker in pacemaker dependent patients submitted to CRT upgra de.
Source: Europace - Category: Cardiology Source Type: research

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CONCLUSIONS: The degree of reverse remodelling was larger in patients with leads situated in a scar-free LCR. In patients with leads situated within scar there was a neutral effect on reverse remodelling, which can be caused both by higher scar burden or lead position. These findings demonstrate the feasibility of a CMR work-up and potential benefit in ICM patients undergoing CRT. PMID: 31953775 [PubMed - as supplied by publisher]
Source: Netherlands Heart Journal - Category: Cardiology Authors: Tags: Neth Heart J Source Type: research
AbstractBackgroundAssessment of left ventricular mechanical dyssynchrony (LVMD) from gated SPECT myocardial perfusion imaging (MPI) aims to aid selection of patients for cardiac resynchronization therapy (CRT), using either the standard deviation of left ventricular phase (PSD) ≥ 43° or phase histogram bandwidth (HBW) of> 38 ° and> 30.6 ° in males and females, respectively. We observed dyssynchrony parameters might be affected by test type and alignment.MethodsWe reviewed 242 patients who underwent gated SPECT MPI with use of the Emory Cardiac Toolbox comparing PSD and HBW at rest and stress for Pearso...
Source: Journal of Nuclear Cardiology - Category: Nuclear Medicine Source Type: research
AbstractIndications of cardiac resynchronization therapy (CRT) do not include exercise ‐induced left bundle branch block, but functional impairment could be improved with CRT in such cases. A 57‐year‐old woman with idiopathic dilated cardiomyopathy (ejection fraction 23%) presented with New York Heart Association Class IV and recurrent hospitalizations. During heart transplant e valuation, a new onset of intermittent left bundle branch block was observed on the cardiopulmonary exercise test. CRT was implanted, and 97% resynchronization rate was achieved. In 12 month follow‐up, both clinical and prognostic exercise ...
Source: ESC Heart Failure - Category: Cardiology Authors: Tags: Case Report Source Type: research
Conditions:   Heart Failure;   Left Ventricular Systolic Dysfunction;   Left Bundle-Branch Block;   Right Bundle-Branch Block;   Non-Specific Intraventricular Conduction Defect Intervention:   Device: His-bundle pacing. Sponsor:   Imperial College London Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
The aim of the present study was to investigate the utility of the modified frailty index (mFI) to predict outcomes in patients undergoing cardiac resynchronization therapy (CRT) device implantation. A retrospective cohort study of patients undergoing CRT implantation or upgrade over a five-year period was performed. The relationship between the pre-procedural 11-component mFI and clinical outcomes including one-year mortality, peri-procedural and 30-day adverse events, 30-day readmission, length of hospitalization after procedure, and response to CRT defined by changes in left ventricular ejection fraction (LVEF) and end-...
Source: The American Journal of Cardiology - Category: Cardiology Authors: Source Type: research
Conditions:   Heart Failure;   Left Ventricular Systolic Dysfunction;   Left Bundle-Branch Block;   Right Bundle-Branch Block;   Non-Specific Intraventricular Conduction Defect Intervention:   Device: His-bundle pacing. Sponsor:   Imperial College London Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
ConclusionsHF-REF patients present altered chemokines profile compared to the control group. The CRT-related alleviation of HF-REF causes only slight changes in the chemokines concentrations especially in the platelet-associated ones. The precise chemokines role in the HF-REF pathogenesis and their prognostic value remains to be established.
Source: Advances in Medical Sciences - Category: Biomedical Science Source Type: research
Conditions:   Heart Failure;   Left Ventricular Systolic Dysfunction;   Left Bundle-Branch Block;   Right Bundle-Branch Block;   Non-Specific Intraventricular Conduction Defect Intervention:   Device: His-bundle pacing. Sponsor:   Imperial College London Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
CONCLUSIONS: HF-REF patients present altered chemokines profile compared to the control group. The CRT-related alleviation of HF-REF causes only slight changes in the chemokines concentrations especially in the platelet-associated ones. The precise chemokines role in the HF-REF pathogenesis and their prognostic value remains to be established. PMID: 31923769 [PubMed - as supplied by publisher]
Source: Advances in Medical Sciences - Category: Biomedical Science Authors: Tags: Adv Med Sci Source Type: research
AbstractIntroductionWe investigated whether pacing ‐induced electrical dyssynchrony at the time of cardiac resynchronization therapy (CRT) device implantation was associated with chronic CRT response.Methods and resultsWe included a total of 69 consecutive heart failure patients who received a CRT device. Left (LVp ‐RVs) and right (RVp‐LVs) pacing‐induced interlead delays were measured intra‐operatively and used to determine if there was paced left ventricular (LV) dyssynchrony (PLVD), defined as present when LVp‐RVs is larger than RVp‐LVs. CRT response was defined as a reduction in LV end‐systol ic volume ...
Source: Journal of Cardiovascular Electrophysiology - Category: Cardiology Authors: Tags: ORIGINAL ARTICLE Source Type: research
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