Effects of imipramine on cytokines panel in the rats serum during the drug treatment and discontinuation

Publication date: Available online 28 November 2017 Source:Neurochemistry International Author(s): M. Kuśmider, A. Faron-Górecka, P. Pabian, J. Solich, M. Szlachta, M. Kolasa, D. Żurawek, J. Wójcikowski, W. Daniel, M. Dziedzicka-Wasylewska Time dependent sensitization (TDS) - phenomenon described originally by Chiodo and Antelman (1980) in context of dopamine receptors, refers to cascade of events that continue to develop in the organism, after the initiating stimulus is no longer available. Treatment could be recognized as such a initiating stimulus (in case of depression, example of electroconvulsive therapy would be obvious, but some aspects of pharmacotherapy too). The process leads to improvement, but, on the other hand, phenomena of kindling in recurrent depression is well known (more relapses and therapies make heavier and longer lasting subsequent episodes). Hence our interest in delayed effects of treatment. Here we report alterations in rat immune system after Imipramine (IMI) treatment cessation. Wistar male rats were treated with IMI (10 mg/kg i.p. in 2 ml/kg of saline) repeatedly for 21 days or once - on the last day of drug administration period. Then the 3 weeks discontinuation phase begun, during which, at certain time points (3 h, 72 h, 7days, 21days) the trunk blood was collected. Tissue concentrations of IMI and its metabolite desipramine (DMI), as well as ACTH and various cytokines were measured. The IMI and DMI was detectable only 3 h...
Source: Neurochemistry International - Category: Neuroscience Source Type: research