Targeted iron nanoparticles with platinum-(IV) prodrugs and anti-EZH2 siRNA show great synergy in combating drug resistance in  vitro and in vivo.

Targeted iron nanoparticles with platinum-(IV) prodrugs and anti-EZH2 siRNA show great synergy in combating drug resistance in vitro and in vivo. Biomaterials. 2017 Nov 14;155:112-123 Authors: Yu C, Ding B, Zhang X, Deng X, Deng K, Cheng Z, Xing B, Jin D, Ma P, Lin J Abstract Resistance to platinum agents is challenging in cancer treatment with platinum drugs. Such resistant cells prevent effective platinum accumulation intracellular and alter cellular adaptations to survive from cytotoxicity by regulating corresponding proteins expression. Ideal therapeutics should combine resolution to these pump and non-pump relevant resistance of cancer cells to achieve high efficacy and low side effect. Fe3O4 nanocarrier loaded with drugs could enter cells in a more efficient endocytosis manner which circumvents pump-relevant drug resistance. EZH2 protein which was previously found to be over-expressed in drug-resistant cancer cells was reported to be involved in platinum drug resistance and play a vital role in anti-apoptosis pathways. Here, we report Fe3O4 nanoparticles loaded with siEZH2 (siRNA), a platinum prodrug in +4 oxidation state (cis, cis, trans-diamminedichlorodisuccinato-platinum-(IV), namely Pt(IV)) and luteinizing hormone-releasing hormone (LHRH) targeting polypeptides. Results show that targeted nanoparticles loading with siEZH2 synergize with Pt(IV) and result in similar cell killing performance to A2780/DDP cells (cisplatin resistant...
Source: Biomaterials - Category: Materials Science Authors: Tags: Biomaterials Source Type: research

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Abstract Chronic infection with the hepatitis C virus (HCV) is a common cause of chronic liver disease, cirrhosis, and liver cancer. Like most viruses, HCV depends of a number of factors encoded by its host cell to execute its replication cycle and create. Expression cloning is one of several possible approaches that have been employed to identify novel host factors essential for the HCV replication cycle. It involves generation of a cDNA library from a cell type with a desired trait (such as ability to bind E2 or being susceptible to HCV infection), expression of that library in a different cell type missing the ...
Source: Mol Biol Cell - Category: Molecular Biology Authors: Tags: Methods Mol Biol Source Type: research
Authors: Ramesh N, Mandal AKA Abstract Epigallocatechin-3-gallate (EGCG), derived from green tea, is an active phytochemical against many types of cancer, cardiovascular, neurological and inflammatory diseases. However, its pharmaceutical activity is limited due to low bioavailability and chemical instability. To overcome these limitations, we fabricated spherical, EGCG loaded solid lipid nanoparticles (SLN-EGCG) as an oral delivery system. The SLN-EGCG showed a hydrodynamic diameter of 300.2 ± 3.8 nm with the drug encapsulation efficiency of 81 ± 1.4%. Additionally,...
Source: Drug Development and Industrial Pharmacy - Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research
Cindy Roberts is training dogs like her own pet, Nibbler, to detect cancer at her obedience school in Birmingham, Alabama. A new Lake Eerie College study suggests dogs find cancer 97% of the time.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
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Source: Journal of Clinical Engineering - Category: Medical Devices Tags: DEPARTMENTS: Technology and Trends Source Type: research
ConclusionAlthough clinicians should endeavor to offer alternative pain management strategies to all patients, those who are younger, are male patients, and report a history of or current substance use or mental health diagnoses were associated with a greater risk of developing opioid misuse. Clinicians should consider prioritizing alternative pain management strategies for these higher-risk patients.
Source: Annals of Emergency Medicine - Category: Emergency Medicine Source Type: research
Researchers from Uppsala University, Sweden, claim that for every one ovarian cancer case that is detected, five women are operated on, putting them at risk of pain, infection and blood loss.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Publication date: September 2019Source: Steroids, Volume 149Author(s): Cheng-Shi Jiang, Tong Ru, Xia-Juan Huan, Ze-Hong Miao, Yue-Wei GuoAbstractTwo new highly oxygenated ergostane-type sterols (1, 2) together with one known related compound sinugrandisterol A (3) were isolated from the soft coral Sinularia sp. collected from the water area near the Xisha Islands, South China Sea. Their structures were elucidated on the basis of detailed spectroscopic analysis, chemical transformations, and by comparison with those reported in literature. In bioassays, compounds 1 and 2 showed in vitro antiproliferative activity against a ...
Source: Steroids - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 20 June 2019Source: Journal of Pharmaceutical and Biomedical AnalysisAuthor(s): Zur Mira Azizah Nor Haiza Lah, Shahrul Ainliah Alang Ahmad, Muhammad Safwan Zaini, Mazliana Ahmad KamarudinAbstractA facile electrochemical sandwich immunosensor for the detection of a breast cancer biomarker, the human epidermal growth factor receptor 2 (HER2), was designed, using lead sulfide quantum dots-conjugated secondary HER2 antibody (Ab2-PbS QDs) as a label. Using Ab2-PbS QDs in the development of electrochemical immunoassays leads to many advantages such as straightforward synthesis and well-defined ...
Source: Journal of Pharmaceutical and Biomedical Analysis - Category: Drugs & Pharmacology Source Type: research
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Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
Melanoma is one of the deadliest cancers. In this issue, Kobayashi et  al. (2019) demonstrate a novel role for tumor-infiltrating innate-like B1a B cells in promoting melanoma growth. IL-10+ (B1a) regulatory B cells accumulate selectively in melanomas, and enhance tumor growth through suppression of cytokine production by tumor-infiltrating CD8+ T cells and potential ly additional IL-10–dependent mechanisms.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Commentary Source Type: research
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