Cytotoxic ergostane derivatives from the edible mushroom Termitomyces microcarpus (Lyophyllaceae)

Publication date: February 2018 Source:Biochemical Systematics and Ecology, Volume 76 Author(s): Alice W. Njue, Josiah O. Omolo, Peter K. Cheplogoi, Moses K. Langat, Dulcie A. Mulholland Five ergostanes, dimethylincisterol (1), 5α,8α–epidioxy-(22E,24R)-ergosta-6,9(11),22-trien-3β-ol (2), 5α,8α–epidioxy-(22E,24R)-ergosta-6,22-dien-3β-ol (3), 5α,6α-epoxy-(22E,24R)-ergosta-8(14),22-diene-3β,7α-diol (4), (22E,24R)-ergosta-7,22-diene-3β,5α,6β-triol (5) and betulinic acid (6) were isolated from the fresh fruiting bodies of the edible mushroom, Termitomyces microcarpus. The cytotoxicity of the compounds isolated was evaluated against the NCI 60 human cancer cell line panel. The degraded sterol dimethylincisterol (1) and 5α,8α–epidioxyergosta-6,22-dien-3β-ol (3) possessed cytotoxic activity at the 1 μM level. Graphical abstract
Source: Biochemical Systematics and Ecology - Category: Biochemistry Source Type: research