Somatic mosaicism for SLC1A1 mutation supports threshold effect and familial aggregation in schizophrenia spectrum disorders

Schizotypal personality disorder (SPD) is associated with psychotic-like traits and an increased risk for schizophrenia (SCZ). SPD represents therefore a relevant condition to investigate the mechanism of disease progression in schizophrenia spectrum disorders (Barrantes-Vidal et al., 2015). Since the original description by Kallman in 1938 (Kallman, 1938), various psychiatric disorders were reportedly found to aggregate among relatives of SCZ individuals. Conversely, a high risk of SCZ has been reported in offspring of SPD parents (Tsuang, 2000).
Source: Schizophrenia Research - Category: Psychiatry Authors: Tags: Letter to the editor Source Type: research