Can Early Dissection of Cervical Lymph Nodes Improve Prognosis in Squamous Cell Carcinomas of the Hard Palate?
We report a series of patients with squamous cell carcinomas and evaluate the rate of lymph node invasion and its impact on survival. This is a retrospective study of 72 patients treated for squamous cell carcinoma of the hard palate and maxillary alveolar ridge between January 1, 1998 and December 31, 2008 in two cancer centres. Using clinical and radiological assessment, tumours were classified as T1-T2 in 25 patients (34.7%) and T3-T4 in 47 patients (65.3%). At diagnosis, 16 (22.2%) patients had clinical and/or radiological nodal involvement and 7 patients (9.7%) distal metastasis. Among N0 patients, 13 (18%) experienced isolated lymph node recurrence. Two-year global survival was 60%; 5-year survival was 34%. The rate of lymph node invasion observed in squamous cell carcinoma of the hard palate and maxillary alveolar ridge does not differ from other oral cavity sites. Because nodal recurrence worsens the prognosis of such a patient, lymph node dissection should be considered at an early stage, even among N0 patients.ORL 2017;79:314-322
In conclusion, DOI measurement for SCC of the oral tongue may require re-examination of the diagnostic biopsy in up to 20% of cases due to the absence or o nly minimal residual carcinoma in glossectomy specimens. In 11.5% of apparently pT2 cases, DOI may be underestimated due to the positive deep margin. Rarely, extratumoral PNI or lymphatic invasion may be the deepest point of invasion. Overall, two issues (absent or minimal residual disease and posit ive deep margin) may confound DOI measurement in early SCCs of oral tongue.
Conclusion: Both cellular and nuclear variables provide a more accurate indication of tumor aggressiveness than any single parameter. Morphometric analysis can be a reliable tool to determine objectively the degree of malignancy at the invasive tumor front.
Excerpted fromPrecision Medicine and the Reinvention of Human DiseaseDespite having the most advanced healthcare technology on the planet, life expectancy in the United States is not particularly high. Citizens from most of the European countries and the highly industrialized Asian countries enjoy longer life expectancies than the United States. According to the World Health Organization, the United States ranks 31st among nations, trailing behind Greece, Chile, and Costa Rica, and barely edging out Cuba . Similar rankings are reported by the US Central Intelligence Agency . These findings lead us to infer that acc...
Conclusion: Patients with OCSCC who have contralateral lymph node metastasis, tumors with a thickness #x3e;25 mm, angiolymphatic invasion, or locoregional recurrence after surgical treatment have a greater risk of developing distant metastasis.ORL 2017;79:347 –355
Squamous cell carcinoma of the head and neck (HNSCC) contributes substantially to the global burden of cancer [1 –3]. It is the sixth most common cancer worldwide , and the fifth most common cancer in the United States, affecting approximately 40,000 new patients each year . It encompasses cancers of the oral cavity, oropharynx, and larynx among others. While the mortality rate for HNSCC has improved r ecently, it still has poorer survival rates than some other common malignancies such as breast, cervical, and colorectal cancers [5,6].
Authors: Kuo IC, Kao HK, Huang Y, Wang CI, Yi JS, Liang Y, Liao CT, Yen TC, Wu CC, Chang KP Abstract Oral cavity squamous cell carcinoma (OSCC) is a leading cause of cancer-related deaths worldwide and associated with poor prognosis and mortality. Discovery of proteins that can improve OSCC treatment is needed. Using comparative proteome profiling of primary cells derived from OSCC and adjacent noncancerous epithelium, endoplasmic reticulum aminopeptidases 2 (ERAP2) has been identified as an OSCC-associated protein. Compared with the adjacent normal tissues, ERAP2 levels were determined to be significantly elevated...
Conclusion: Our study highlight the better diagnostic value of PET/MR staging in primary tumor than cervical node for head and neck malignancies with 94% of the primary tumor and 82% of the regional nodes well-classified in comparison to pathology. One explanation lies on the insufficiency of the attenuation correction, but the high quality of images combined to the multimodal approach of PET/MR strengthens the diagnostic confidence by better tumor delineation and cervical node characterization. Therefore this modality appeared beneficial and promising for clinical practice. Research Support: Pitié-Salpêtrière Hospital
ConclusionThe results suggest that although there was dysregulation of cell cycle regulatory proteins, only Ki‐67 and the MCM2/Ki‐67 and geminin/Ki‐67 ratios may have prognostic significance in oral cancer. DNA ploidy alone was not specific and may not be a good tool to evaluate prognosis or metastatic progression in oral cavity carcinomas.This article is protected by copyright. All rights reserved.
Publication date: Available online 21 December 2016 Source:Journal of Cranio-Maxillofacial Surgery Author(s): Angel Rollon-Mayordomo, Teresa Creo-Martinez, Yolanda Marin-Lapeira, Juan-Andres Rodriguez-Ruiz, Pedro Infante-Cossio The aim of this study was to evaluate preoperative ultrasound criteria to detect lymph node (LN) cervical metastasis in patients with clinically node-negative neck (cN0) oral cavity squamous cell carcinoma (OCSCC). A prospective, single-center, observational study was conducted in 90 patients undergoing cancer excision with or without elective neck dissection (END) between 2005 and 2012. A surgeon ...
Conclusions The present data do not provide evidence for a role of genetic variations in EVER1 or EVER2 for HPV status of mucosal HNSCC or between HNSCC patients and controls.