Primary replication and invasion of the bovine gammaherpesvirus BoHV-4 in the genital mucosae

In this study, in vivo-related in vitro genital tract models were successfully established and the early stage of the p athogenesis of a genital infection was clarified: BoHV-4 starts with a productive infection of epithelial cells in the reproductive tract, forming small foci followed by a non-productive infection of surveilling monocytic cells which help BoHV-4 to invade into deeper tissues.
Source: Veterinary Research - Category: Veterinary Research Source Type: research