Ductal cells of minor salivary glands in Sj ögren's syndrome express LINE‐1 ORF2p and APOBEC3B

ConclusionsL1 ORF2p and APOBEC3B are expressed in the ductal epithelial cells of minor salivary glands that are among the key targets in Sjögren's syndrome. L1 ORF2p expression may promote the L1 ability to act as an intrinsic antigen in Sjögren's syndrome. The potential future use of L1 ORF2‐reverse transcriptase inhibitors in autoimmunity supports further investigation of L1 epigenetic regulation by APOBEC3 enzymes.

Source: Journal of Oral Pathology and Medicine - November 28, 2017 Category: Pathology Authors: Eleni ‐Marina Kalogirou, Evangelia P. Piperi, Konstantinos I. Tosios, Evangelos Tsiambas, Galinos Fanourakis, Alexandra Sklavounou Tags: ORIGINAL ARTICLE Source Type: research