Severe neonatal thrombocytopenia due to fetomaternal anti-A alloimmunization: A  case report

Fetal or neonatal alloimmune thrombocytopenia (FNAIT) results from a maternal alloimmunization against fetal platelet (PLT) antigens. FNAIT is the most common cause of severe fetal and neonatal thrombocytopenia in maternity wards. The most feared complication of FNAIT is the occurrence of intracranial hemorrhage. To date, 35 human platelet antigens (HPAs) have been described. NAIT can rarely be caused by other antigens expressed at the platelet surface, such as blood group A and B antigens. Here, we report the case of a transient but severe neonatal alloimmune thrombocytopenia due to an anti-A maternal alloantibody.
Source: Pediatrics and Neonatology - Category: Perinatology & Neonatology Authors: Tags: Short Communication Source Type: research