How comorbid conditions affect the choice of treatment in multiple sclerosis

A person can have more than one medical illness at the same time. For instance, a person could have headaches and also have low thyroid. In some cases, the medical illnesses are unrelated. In other instances, the comorbid illnesses occur together more often than by chance alone. In medicine, comorbid illnesses are very common. Many prior Patient Pages have discussed some of these associations. For people with multiple sclerosis (MS), having a comorbid medical condition is common. In some studies, 40%–66% of people with MS will also have another, associated, medical condition.
Source: Neurology - Category: Neurology Authors: Tags: All Demyelinating disease (CNS), Multiple sclerosis PATIENT PAGES Source Type: research

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We present a case presenting with characteristic features of HaNDL and an MRI lesion in the splenium of corpus callosum. CSF neurofilament light chain (NFL) levels were assessed in this patient together with 7 additional HaNDL patients, 18 multiple sclerosis (MS) patients, and 15 primary headache patients. Both HaNDL and primary headache patients showed significantly lower NFL levels than MS patients. Our results suggest that increased CSF levels of NFL and neuroaxonal loss are not characteristic features of HaNDL. Neurological disorders mimicking HaNDL often present with increased levels of NFL, and thus CSF measurement o...
Source: Case Reports in Neurology - Category: Neurology Source Type: research
CONCLUSIONS Neuroinflammation due to CTLA4h is mediated primarily by an infiltrative process with a distinct and striking dissociation between clinical symptoms and radiological findings in the majority of patients.FUNDING NIAID, NIH, Division of Intramural Research, NINDS, NIH, Division of Intramural Research, and the National Multiple Sclerosis Society–American Brain Foundation.TRIAL REGISTRATION ClinicalTrials.gov NCT00001355.
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Publication date: November 2020Source: Multiple Sclerosis and Related Disorders, Volume 46Author(s): Mia T. Minen, Kathryn B. Schaubhut, Kaitlyn Morio
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Conclusion: Since CADASIL is a rare disease, it is imperative to raise awareness of its unique clinical condition as well as variation in its clinical presentations. It is crucial that the overlapping symptoms between MS and CADASIL be thoroughly examined to avoid misdiagnosis and treatment complications. The involvement of autoimmune mechanisms in CADASIL and the role of NOTCH3 gene mutations in provoking an autoimmune process should be further investigated.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
ConclusionComorbidities are common at MS symptom onset and increase with MS duration. Having MS may thus contribute to accrual of comorbidities. This emphasises the importance of optimal screening for and management of comorbidities in early MS and throughout the disease course.
Source: Journal of Neurology - Category: Neurology Source Type: research
WEDNESDAY, Aug. 26, 2020 -- Internationally, more than three in 10 patients with multiple sclerosis (MS) have migraine, according to a review published in the September issue of the Journal of Clinical Neuroscience. Omid Mirmosayyeb, M.D., from...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
AbstractPurpose of ReviewThe purpose of this review is to evaluate and explain our current understanding of the clinical use of low-dose naltrexone in the treatment of chronic pain.Recent FindingsRecent pre-clinical uses and clinical studies further elucidate the use of low-dose naltrexone in the treatment of chronic pain.SummaryLow-dose naltrexone (LDN) has shown promise to reduce symptoms related to chronic pain conditions such as fibromyalgia, inflammatory bowel conditions, and multiple sclerosis. The mechanism of LDN appears to be modulation of neuro-inflammation, specifically, the modulation of the glial cells and rel...
Source: Current Pain and Headache Reports - Category: Neurology Source Type: research
Publication date: September 2020Source: Journal of Clinical Neuroscience, Volume 79Author(s): Omid Mirmosayyeb, Mahdi Barzegar, Nasim Nehzat, Vahid Shaygannejad, Mohammad Ali Sahraian, Mahsa Ghajarzadeh
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
Conclusions: PRS may be associated with autoimmune pathogenesis, but the present case does not support that theory.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Abstract The relationship between headache and multiple sclerosis (MS) has been a matter of controversy for over 60 years. Headaches are still rated as a "red flag", indicating alternative diagnoses to MS, although in the last few years numerous studies have shown a frequent association between headache and MS. In recent studies on MS patients, a link was found between lower age/shorter disease duration of MS and frequent headaches. A study of 50 patients manifesting MS for the first time showed the highest headache prevalence in MS of 78% reported so far.Headaches can also be a&...
Source: Der Nervenarzt - Category: Neurology Authors: Tags: Nervenarzt Source Type: research
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