Teaching NeuroImages: Brain imaging findings in acute methanol toxicity

A 35-year-old man presented to the hospital in status epilepticus. CT of the head revealed bilateral basal ganglia hemorrhage (figure, A). Serum osmolality was elevated at 372 mmol/kg and methanol level was 34 mmol/L. He was admitted to the intensive care unit. MRI of the brain (figure, B–D) demonstrated extensive white matter diffusion restriction and basal ganglia hemorrhage. Care was withdrawn on postadmission day 6, with the patient dying shortly thereafter. Methanol toxicity classically presents with putaminal necrosis, presumed secondary to cellular hypoxia from formate-induced cytochrome oxidase inhibition.1 Rarely, white matter necrosis is evident on MRI.1
Source: Neurology - Category: Neurology Authors: Tags: CT, MRI, All Toxicology, Alcohol, Other toxicology RESIDENT & amp;amp; FELLOW SECTION Source Type: research

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The objective of this study was to determine whether implementation of geriatric-specific trauma team activation (TTA) protocols appropriately identified severely-injured elderly patients. METHODS: This single-center retrospective study evaluated all severely injured (injury severity score [ISS]>15), geriatric (≥65 years) patients admitted to our Level 1 tertiary-care hospital between January 2014 and September 2017. Undertriage was defined as the lack of TTA despite presence of severe injuries. The primary outcome was all-cause in-hospital mortality; secondary outcomes were mortality within 48 hours of admissio...
Source: The American Surgeon - Category: Surgery Authors: Tags: Am Surg Source Type: research
Authors: Ţolescu RŞ, Zorilă MV, Şerbănescu MS, Kamal KC, Zorilă GL, Dumitru I, Florou C, Mogoantă L, Văduva IA, Stanca L, Zăvoi RE Abstract Deaths caused by traumatic brain injury (TBI) increase in incidence every year worldwidely, mainly in developing countries. Thus, World Health Organization (WHO) estimates that in 2020, TBI will become the third main cause of death. In our study, we evaluated the deaths caused by TBI recorded within the Institute of Forensic Medicine of Craiova, Romania, between 2011 and 2017. Therefore, according to age, the cases were divided into two groups: people aged 0-18 years o...
Source: Romanian Journal of Morphology and Embryology - Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research
Conclusions: MiR-18a may have significant clinical value in preventing, reducing and potentially reversing AVM. PMID: 32755283 [PubMed - as supplied by publisher]
Source: Circulation Research - Category: Cardiology Authors: Tags: Circ Res Source Type: research
Conclusion: Ischemic stroke might not be associated with portal vein thrombosis in liver cirrhosis. PMID: 32714987 [PubMed - in process]
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
oi Hong This cross-sectional study aimed to evaluate the association between periodontitis and cardiovascular disease (CVD) by reviewing and discussing the role of the oral microbiome in periodontitis and CVD. This prospective cohort study used epidemiological data from the Korean Genome and Epidemiology Study from 2004 to 2016. We selected 9973 patients with periodontitis and 125,304 controls (non-periodontitis) from 173,209 participants and analyzed their medical histories to determine the relationship between cerebral stroke/ischemic heart disease and periodontitis. The participants were questioned about any prev...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
Intracerebral hemorrhage (ICH), caused by a rupture of a brain artery into brain parenchyma, is the second most common form of stroke after ischemic stroke.1 Approximately 40% of the patients die within one month, and many remain with major disabilities.2 There is no effective medical or surgical treatment option, and those in clinical use are mainly supportive in nature, even though management in dedicated stroke units will likely reduce mortality and morbidity.3 Several chronic risk factors such as hypertension, older age, and high alcohol consumption have been shown to associate with ICH.
Source: Journal of Stroke and Cerebrovascular Diseases - Category: Neurology Authors: Source Type: research
CONCLUSION: Our results suggest that long-term exposure to SPM is associated with an increased risk of all cardiovascular mortality for men in Ibaraki, Japan. PMID: 32641588 [PubMed - as supplied by publisher]
Source: Journal of Atherosclerosis and Thrombosis - Category: Cardiology Tags: J Atheroscler Thromb Source Type: research
Authors: Susmitha K, Chandrasekhar V, Kiran G, Divya A, Rani GS, Sarangapani M Abstract Stroke is becoming a main cause of early death and disability in developing countries like India, and it is mostly enhanced by increased predominance of major risk factors. A detailed knowledge about the nature and magnitude of the stroke cases in this particular area is not only important for acute treatment but also it helps to prevent hospital admissions due to reoccurring stroke. The present study was conducted in the Department of Stroke at MGM Hospital, Warangal, India, to study the patterns of stroke admissions. All the c...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Conclusions: Comorbidities such as chronic hypertension and kidney failure were less frequent than in patients with other PRES etiologies. Imaging analysis did not highlight a specific pattern for poisoning-induced PRES. Although less described, PRES in the context of poisoning, which shares most of the clinical and radiological characteristics of other etiologies, is not to be ignored.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Background: Hypertension is a well-known risk factor for intracerebral hemorrhage (ICH). On many of the other potential risk factors, such as smoking, diabetes, and alcohol intake, results are conflicting. We assessed risk factors of ICH, taking also into account prior depression and fatigue. Methods: This is a population-based case-control study of 250 primary ICH patients, conducted in Helsinki University Hospital, Finland. The controls (n  = 750) were participants of the FINRISK study, a large Finnish population survey on risk factors of chronic noncommunicable diseases, matched with cases by sex and age.
Source: Journal of Stroke and Cerebrovascular Diseases - Category: Neurology Authors: Source Type: research
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