Design, synthesis and fungicidal activity studies of 3-ferrocenyl-N-acryloylmorpholine

Publication date: Available online 26 November 2017 Source:Journal of Organometallic Chemistry Author(s): Peiqi Chen, Chunjuan Liu, Jianfeng Hu, Hao Zhang, Ranfeng Sun Ferrocene and its derivatives have been widely used in many fields and also used to modify and improve the performance. Particularly, their low toxicity also attract much attention in medical and pesticide fields. In order to get fungicides with higher biological activity, ferrocenyl were introduced into the skeleton of dimethomorph instead of phenyl and a series of 3-ferrocenyl-N-acryloylmorpholine were synthesized. The fungicidal bioassay results indicated that most of compounds showed moderate fungicidal activities against 14 kinds of agricultural pathogenic fungi and some compounds displayed higher fungicidal activities than that of dimethomorph. Intrestlingly, compounds 5(Z) exhibited better fungicidal activity against Sclerotinia sclerotiorum than that of compound 5(E). Graphical abstract

Source: Journal of Organometallic Chemistry - November 27, 2017 Category: Chemistry Source Type: research