Asthma: U.S. FDA approves new indication for SPIRIVA ® Respimat®

Asthma: U.S. FDA approves new indication for SPIRIVA ® Respimat®
Source: Boehringer Ingelheim Corporate News - Category: Research Source Type: news

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Publication date: Available online 20 June 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Makoto Hoshino, Kenta Akitsu, Kengo KubotaAbstractBackgroundThe efficacy of the standardized quality (SQ) house dust mite (HDM) sublingual immunotherapy (SLIT) has been demonstrated for respiratory allergic disease. However, the effect of SLIT on inflammation and structural changes of the airways are still unknown.ObjectiveThe aim of this study was to assess the effects of the 6 SQ-HDM SLIT on airway inflammation and airway geometry in allergic asthma and rhinitis.MethodsOne hundred two asthmatic pat...
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
THURSDAY, June 20, 2019 -- In an effort to improve the lives of millions of people with asthma, researchers say they've completed the first mapping of lung and airway cells, which may lead to new therapies for the common lung condition. The mapping...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
Authors: Zhang YZ, Wu QJ, Yang X, Xing XX, Chen YY, Wang H Abstract OBJECTIVE: Asthma is the most common chronic airway inflammatory disease. Sirtuin 1 (SIRT1) exerts a crucial effect on regulating chronic inflammatory responses. Therefore, this study aims to explore the effect of SIRT1 on the pathogenesis of asthma. MATERIALS AND METHODS: Serum level of SIRT1 in asthma patients and healthy controls was detected by Western blot. Correlation between SIRT1 level and pulmonary function in asthma patients was analyzed. Subsequently, asthma model in mouse was established. Primary airway epithelial cells were extract...
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Authors: Rodrigues MA, Nogueira M, Torres T Abstract Atopic dermatitis (AD) is a common chronic, pruritic inflammatory dermatosis. The inflammatory response is characterized by a T helper 2 (Th2) immune response phenotype. Topical therapy is the main treatment in mild-to-moderate AD, but many cases of moderate-to-severe require systemic treatments. Dupilumab is the first biologic approved for the treatment of adults with moderate-to-severe AD. It inhibits IL-4 and IL-13 signaling pathways and reduces Th2 response. Clinical trials have demonstrated significantly improved clinical and patient-reported outcomes. The a...
Source: Giornale Italiano di Dermatologia e Venereologia - Category: Dermatology Tags: G Ital Dermatol Venereol Source Type: research
Source: FDA Drug Safety Podcasts - Category: Drugs & Pharmacology Authors: Source Type: podcasts
Publication date: Available online 19 June 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Priyadarshini Kachroo, Rachel S. Kelly, Hooman Mirzakhani, Kathleen Lee-Sarwar, Bo L. Chawes, Kevin Blighe, Ganmaa Davaasambuu, Hans Bisgaard, Augusto A. Litonjua, Scott T. Weiss, Jessica Lasky-Su
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
This study aimed to characterize the inflammatory profiles and investigate the effect of atopy on the pathogenesis of pediatric ACPs.
Source: Allergy, Asthma and Clinical Immunology - Category: Allergy & Immunology Authors: Tags: Research Source Type: research
Th2 cells play a pathogenic role in allergies such as asthma, yet a clear picture of their transcriptional profile in this setting is lacking. Tibbitt, Stark, et  al. elucidate a distinct gene expression signature in Th2 cells responding to house dust mites and show that pathogenic airway Th2 cells are highly enriched for genes associated with lipid metabolism.
Source: Immunity - Category: Allergy & Immunology Authors: Tags: Resource Source Type: research
Background Historical data suggest 15% of laboratory animal workers develop IgE sensitisation and 10% symptoms of laboratory animal allergy (LAA), including occupational asthma. Individually ventilated cages (IVCs) are replacing conventional open cages; we sought to evaluate their impact on the development of LAA. Methods We surveyed 750 laboratory animal workers and measured airborne Mus m 1 (mouse allergen) levels in seven UK institutions. We compared the prevalence of sensitisation to mouse proteins (by specific IgE assay or skin prick test) and of work-related allergic symptoms in IVC-only and open cage units. Result...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Asthma and allergy Original Articles: Asthma and allergy Source Type: research
Interleukin 1 receptor-like 1 (IL1RL1), also known as suppression of tumorigenicity 2 (ST2), is the receptor for interleukin 33 (IL-33) and has been increasingly studied in type 2 inflammation. An increase in airway IL-33/ST2 signaling in asthma has been associated with eosinophilic inflammation, but little is known about the role of ST2 in neutrophilic inflammation. Airway Mycoplasma pneumoniae and human rhinovirus (HRV) infections are linked to neutrophilic inflammation during acute exacerbations of asthma. However, whether ST2 contributes to M. pneumoniae- and HRV-mediated airway inflammation is poorly understood. The c...
Source: Infection and Immunity - Category: Infectious Diseases Authors: Tags: Host Response and Inflammation Source Type: research
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