Pradaxa ® (dabigatran etexilate) 150mg bid continues to be the only oral anticoagulant which showed superior ischaemic stroke reduction vs. warfarin in its pivotal study RE-LY® – Results of the ENGAGE AF-TIMI 48 trial published for edoxaban vs. warfarin do

Pradaxa ® (dabigatran etexilate) 150mg bid continues to be the only oral anticoagulant which showed superior ischaemic stroke reduction vs. warfarin in its pivotal study RE-LY® – Results of the ENGAGE AF-TIMI 48 trial published for edoxaban vs. warfarin do
Source: Boehringer Ingelheim Corporate News - Category: Research Source Type: news

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Publication date: Available online 25 January 2020Source: Journal of Clinical NeuroscienceAuthor(s): Juliane Herm, Alexander Schirdewan, Lydia Koch, Alexander Wutzler, Jochen B. Fiebach, Matthias Endres, Ute A. Kopp, Karl Georg HaeuslerAbstractAtrial fibrillation (AF) is associated with cognitive decline and dementia irrespective of AF-related ischemic stroke. We investigated whether AF burden after ablation in patients with symptomatic paroxysmal AF has an impact on cognitive function. After enrolment to the prospective MACPAF study, study patients received an insertable loop recorder (ILR) and underwent serial neurologic...
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
Publication date: Available online 25 January 2020Source: Clinica Chimica ActaAuthor(s): Guo-Hai Zhang, Zhe-Hao Ye, Hao-Jie Guan, Mi Guo, Xin-Xiang Zhou, Yu-Yu XuAbstractBackgroundReduced serum omentin-1 concentrations might be related to an increased risk for poor functional outcome after acute ischemic stroke. We intended to explore whether serum omentin-1 could be a promising prognostic biomarker for acute intracerebral hemorrhage.MethodsA total of 104 consecutive patients with hemorrhagic stroke underwent 90-day follow-up. The modified Rankin scale score> 2 was evaluated as worse prognosis. A multivariable logistic ...
Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
CONCLUSION: HFpEF confers a significant perioperative risk of MACCE in patients undergoing hip fracture surgery. PMID: 31977615 [PubMed - in process]
Source: The Journal of the American Academy of Orthopaedic Surgeons - Category: Orthopaedics Tags: J Am Acad Orthop Surg Source Type: research
CONCLUSION: This paper provides a new hybrid GSA-RDF classifier technique to segment the ischemic stroke lesions in MR images. The experimental results demonstrate that the proposed technique has the Root Mean Square Error (RMSE), Mean Absolute Percentage Error (MAPE), and Mean Bias Error (MBE) ranges are 16.5485 %, 7.2654 %, and 2.4585 %individually. The proposed RDF-GSA algorithm has better precision and execution when compared with the existing ischemic stroke segmentation method. PMID: 31975663 [PubMed - in process]
Source: Current Medical Imaging Reviews - Category: Radiology Tags: Curr Med Imaging Rev Source Type: research
CONCLUSION: As reimbursement for emergency medicine in Germany was recently rearranged, quality benchmarking has gained incremental importance. Mandatory joint quality measurement in both concepts ensuring gap analysis and process improvement is encouraged. PMID: 31970463 [PubMed - as supplied by publisher]
Source: Herz - Category: Cardiology Tags: Herz Source Type: research
ConclusionAbout two third of the patients had poor treatment outcome. Educational status and mean length of hospital stays were independent predictors of poor treatment out-comes. An emergency care setup capable of early patient evaluation, identification and management of stroke complications is crucial to overcome early stroke related mortality.
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
CONCLUSIONS: Low EPA/AA ratio at baseline and treatment without statins could predict mortality, recurrent ischemic stroke, cardiovascular and peripheral artery diseases, and hemorrhagic stroke among patients with acute ischemic stroke. The combination of baseline EPA/AA ratio and statin therapy could be critical in predicting the long-term prognosis of ischemic stroke patients. PMID: 31969533 [PubMed - as supplied by publisher]
Source: Journal of Atherosclerosis and Thrombosis - Category: Cardiology Tags: J Atheroscler Thromb Source Type: research
Authors: Esenwa C, Lekoubou A, Bishu KG, Small K, Liberman A, Ovbiagele B Abstract Background: Compared with non-Hispanic Whites (NHW), racial-ethnic minorities bear a disproportionate burden of stroke and receive fewer evidence-based stroke care processes and treatments. Since 2015, mechanical thrombectomy (MT) has become standard of care for acute ischemic stroke (AIS) patients with proximal anterior circulation large vessel occlusion (LVO). Objectives: Our objectives were to: assess recent trends in nationwide MT utilization among patients with AIS; determine if there were racial differences; and identify wh...
Source: Ethnicity and Disease - Category: International Medicine & Public Health Tags: Ethn Dis Source Type: research
ConclusionsThis study indicated that exercise combined with low-level inhibition of GABAA receptors after stroke could facilitate the recovery of motor function accompanied by BDNF upregulation in the ipsilateral M1. Therefore, this study provides a novel insight of pharmacological neuromodulation into stroke rehabilitation.
Source: Neuroscience - Category: Neuroscience Source Type: research
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