ERS Congress 2013 New Phase III data presented for first time demonstrate: tiotropium* Respimat ® significantly improves lung function and provides sustained bronchodilation in asthma patients who remain symptomatic despite ICS† treatment

ERS Congress 2013 New Phase III data presented for first time demonstrate: tiotropium* Respimat ® significantly improves lung function and provides sustained bronchodilation in asthma patients who remain symptomatic despite ICS† treatment
Source: Boehringer Ingelheim Corporate News - Category: Research Source Type: news

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Effect of triple therapy in patients with asthma-COPD overlap
. Int J Clin Pharmacol Ther. 2019 Jun 24;: Authors: Ishiura Y, Fujimura M, Ohkura N, Hara J, Kasahara K, Ishii N, Tamaki T, Shimizu T, Nomura S Abstract OBJECTIVE: Asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) is of increasing interest because ACO patients have significantly worse outcomes, leading to greater social and economic burdens compared with asthma or COPD alone. Some guidelines for ACO recommend triple therapy with inhaled corticosteroids, long-acting β2 agonists, and long-acting muscarinic antagonists. H...
Source: International Journal of Clinical Pharmacology and Therapeutics - Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research
Clinical Outcome Assessments (COA) Qualification Submissions Office of Drug Evaluation (ODE) II Division of Pulmonary, Allergy, and Rheumatology Products (DPARP) DDT COA Number DDT COA #000006
Source: FDA Center for Drug Evaluation and Research - What's New - Category: Drugs & Pharmacology Authors: Source Type: news
Clinical Outcome Assessments (COA) Qualification Submissions Office of Drug Evaluation (ODE) II Division of Pulmonary, Allergy, and Rheumatology Products (DPARP) DDT COA Number DDT COA #000099
Source: FDA Center for Drug Evaluation and Research - What's New - Category: Drugs & Pharmacology Authors: Source Type: news
This study investigated effects of exposure to PM2.5, O3, and pollen on asthma control status among pediatric patients with asthma.MethodsA total of 229 dyads of pediatric patients with asthma and their parents were followed for 15 months. The Asthma Control and Communication Instrument was used to measure asthma control, which was reported weekly by parents during a 26-week period. PM2.5 and O3 data were collected from the US Environmental Protection Agency Air Quality System. Pollen data were obtained from Intercontinental Marketing Services Health. Mean air pollutant and pollen exposures within 7 days before the reporti...
Source: Academic Pediatrics - Category: Pediatrics Source Type: research
Condition:   Asthma Intervention:   Sponsors:   University Hospital Southampton NHS Foundation Trust;   Novartis;   Boehringer Ingelheim;   National Institutes of Health (NIH);   Owlstone Ltd;   National Institute for Health Research, United Kingdom Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
In this study, we analysed the promoters of sixteen genes related to the Vitamin D pathway and the high-affinity IgE receptor, including FCER1A, MS4A2, FCER1G, VDR, GC, CYP2R1, CYP27A1, CYP27B1, CYP24A1, RXRA, RXRB, RXRG, IL4, IL4R, IL13, and IL13RA1. The study group was composed of patients with allergic rhinitis plus asthma (AR+A), patients with hypersensitivity to beta-lactams (BLs), to NSAIDs including selective hypersensitivity (SH) and cross-reactivity (CR), and healthy controls without antecedents of atopy or adverse drug reactions. We identified 148 gene variations, 43 of which were novel. Multinomial analyses rev...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
ConclusionThe E/M ratio is a useful predictor for the recurrence of CRSwNP in the Chinese population.
Source: International Forum of Allergy and Rhinology - Category: Allergy & Immunology Authors: Tags: ORIGINAL ARTICLE Source Type: research
Biological pathways underlying severe asthma can be divided broadly into T2hi and T2low, with T2hi having a greater presence of type 2 innate lymphoid and helper T cells, the cytokines interleukin (IL)-4, IL-5, IL-13 and eosinophils, while T2low may show lack of inflammation or neutrophil predominance driven by Th1 and Th17 cells and the related cytokines IL-17 and interferon- γ.1-3 In the past few years, more targeted biologic therapies have become available which specifically block T2 pathways and for which biomarkers such as immunoglobulin E (IgE) or blood eosinophil levels are utilized.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Letters Source Type: research
To review the cost-effectiveness of food allergy management strategies.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Review Article Source Type: research
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research
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