Creation of expert centers on endometriosis.

[Creation of expert centers on endometriosis]. Presse Med. 2017 Nov 20;: Authors: Daraï E, Bendifallah S, Chabbert-Buffet N, Golfier F Abstract Endometriosis is a frequent pathology with a high incidence of deep infiltrating endometriosis and complex forms that can affect 20% of patients with endometriosis. The incidence of infertility associated with endometriosis can reach 50%. The complexity of care requires the creation of expert centers working in networks with general practitioners. Criteria for defining these expert centers are being drawn up, based on structural criteria (multidisciplinary consultation meeting), links with medical assistance structures for procreation and activity criteria for severe and complex forms (number of interventions per center and per surgeon). PMID: 29169709 [PubMed - as supplied by publisher]
Source: Presse Medicale - Category: General Medicine Authors: Tags: Presse Med Source Type: research

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ConclusionAs with all human studies, population sampling and study design matter. Heterogeneity of inclusion and diagnostic criteria and selection bias overwhelmingly account for variability in endometriosis prevalence estimated across the literature. Thus, it is difficult to conclude if the lack of observed change in frequency and distributions of endometriosis over the past 30 years is valid.
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
For over 2 decades preimplantation genetic testing (PGT) has been in clinical use to reduce the risk of miscarriage and genetic disease in patients with advanced maternal age and risk of transmitting disease. Recently developed methods of genome-wide genotyping and machine learning algorithms now offer the ability to genotype embryos for polygenic disease risk with accuracy equivalent to adults. In addition, contemporary studies on adults indicate the ability to predict polygenic disorders with risk equivalent to monogenic disorders. Existing biobanks provide opportunities to model the clinical utility of polygenic disease...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Conditions:   Endometriosis;   Uterine Diseases;   Endometrial Diseases;   Infertility Unexplained;   Infertility; Female, Nonimplantation Interventions:   Drug: EX-527 (Selisistat);   Drug: Placebo Sponsor:   Wake Forest University Health Sciences Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: Available online 2 December 2019Source: Best Practice &Research Clinical Endocrinology &MetabolismAuthor(s): Jamilya Khizroeva, Cecilia Nalli, Victoria Bitsadze, Andrea Lojacono, Sonia Zatti, Laura Andreoli, Angela Tincani, Yehuda Shoenfeld, Alexander MakatsariyaAbstractInfertility consists by definition in ” failure to achieve a clinical pregnancy after 12 months or more of regular unprotected intercourse” while the term subfertility means a delay to achieve pregnancy. Several factors can contribute to infertility or subfertility in patients with systemic autoimmune diseases. The asso...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - Category: Endocrinology Source Type: research
Contributors : Jae-Wook Jeong ; Tae KimSeries Type : Expression profiling by arrayOrganism : Mus musculusMIG-6 loss caused progesterone resistance through ERBB2 overexpression in non-receptive endometrium of endometriosis-related infertility.We used microarrays to understand the molecular mechanisms of progesterone resistance in infertility
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research
Publication date: Available online 27 November 2019Source: Journal of Minimally Invasive GynecologyAuthor(s): Paola Vigano, Jessica Ottolina, Ludovica Bartiromo, Giulia Bonavina, Matteo Schimberni, Roberta Villanacci, Massimo CandianiABSTRACTEndometriosis-related fibrosis represents a complex phenomenon with underlying mechanisms still to be clarified. Fibrosis is consistently present in all disease forms and contributes to classic endometriosis-related symptoms of pain and infertility. The purpose of this literature review was to examine the role of various cellular populations and biological mechanisms/signaling pathways...
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
Publication date: Available online 25 November 2019Source: Saudi Journal of Biological SciencesAuthor(s): Xiaoliang Mo, Yachang ZengAbstractIn order to study the relationship between ovarian endometriosis and clinical pregnancy, explore the correlation between endometriosis (EMT) and abortion rate and its mechanism, and provide a new theoretical basis for clinical diagnosis as well as treatment of endometriosis, in this study, pelvic endometriosis under 40 years old and have in vitro fertilization-embryo transfer (IVF-ET) operation will be selected as subjects of study. SPSS20.0 statistical software is used to analyze the ...
Source: Saudi Journal of Biological Sciences - Category: Biology Source Type: research
ConclusionsEndometriosis reduces the FORT and the number of metaphase-II oocytes after controlled ovarian hyperstimulation independly of women ’s age, antral follicle count and anti-Müllerian hormone.
Source: Archives of Gynecology and Obstetrics - Category: OBGYN Source Type: research
Conditions:   Infertility;   Endometriosis Interventions:   Drug: Elagolix 200 MG;   Drug: Placebo Sponsors:   Yale University;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD);   University of Colorado, Denver;   Northwestern University;   University of North Carolina Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Infertility;   Endometriosis Interventions:   Drug: Elagolix 200 MG;   Drug: Placebo Sponsors:   Yale University;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD);   University of Colorado, Denver;   Northwestern University;   University of North Carolina Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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