C-PTSD and Interpersonal Relationships
As I have discussed in other articles, Complex Post Traumatic Stress Disorder (C-PTSD) is a unique condition that is the result of suffering a series of traumatic incidents over a long period of time at the hands of someone the victim has a dependent relationship with, usually a parent or other primary caregiver. C-PTSD shares many features of the better known PTSD (Post Traumatic Stress Disorder) which is the result of a small number of impersonal traumas, such as car accidents. However, it also has many unique features, which give it a dual nature, in some ways more similar to some personality disorders, or other disorders such as bipolar disorder, with which it is often confused. In my work with clients who suffer from C-PTSD, I am frequently struck with how difficult it is for them to lead fulfilling lives. It is one thing to analyze symptoms like dissociation, emotional dysregulation, depression, or anxiety, but another to appreciate how they interfere with the life of C-PTSD victims on a daily basis. One of the most tragic ways that plays out is the way that C-PTSD makes it difficult for sufferers to form and sustain strong and fulfilling interpersonal relationships. While there are some people who are genuinely happiest on their own, for the vast majority, successful relationships are essential to long-term happiness and life satisfaction. The difficulty that sufferers from C-PTSD face in maintaining stable relationships, is, in fact, one of the major obstacles to the...
Conclusion: The changes in the ocular posterior structure may serve as evidence of the trigeminovascular system mechanism underlying migraine and transneuronal retrograde degeneration of the primary visual cortex, which reflects the cortical spreading depression.Eur Neurol 2018;80:130 –137
Kaziya M. Lee, Michal A. Coelho, MacKayla A. Class, Kimberly R. Sern, Mark D. Bocz, Karen K. Szumlinski
Hilda M. R. M. Constant, Carmen Moret-Tatay, Mariana Canellas Benchaya, Margareth da S. Oliveira, Helena M. T. Barros, Maristela Ferigolo
Conclusion: Costunolide triggers cell shrinkage and phospholipid scrambling of the erythrocyte cell membrane, an effect at least in part due to Ca2+ entry and paralleled by oxidative stress and ceramide formation.Cell Physiol Biochem 2018;50:2283 –2295
Activating mutations in the Wnt pathway drive a variety of cancers, but the specific targets and pathways activated by Wnt ligands are not fully understood. To bridge this knowledge gap, we performed a comprehensive time-course analysis of Wnt-dependent signaling pathways in an orthotopic model of Wnt-addicted pancreatic cancer, using a porcupine (PORCN) inhibitor currently in clinical trials, and validated key results in additional Wnt-addicted models. The temporal analysis of the drug-perturbed transcriptome demonstrated direct and indirect regulation of more than 3,500 Wnt-activated genes (23% of the transcriptome). Reg...
Having genetic variants linked to high BMI can lead to mental health issues, study findsBeing overweight can cause depression, researchers say, with the effects thought to be largely psychological.While previous studies have found that people who are obese are more likely to have depression, it has been unclear whether that is down to depression driving weight changes or the reverse.Continue reading...
ConclusionAnxiety related to “displacement” (not “replacement”) of radiologists by AI discouraged many medical students from considering the radiology specialty. The radiology community should educate medical students about the potential impact of AI, to ensure radiology is perceived as a viable long-term career choice.
Scientists at Exeter University who looked at the genes of 340,000 people found those with a high body mass index (BMI) were more likely to suffer depression, the researchers found.
Erin Hoare, Meghan Hockey, Anu Ruusunen, Felice N. Jacka