Say hello to our new pal - PALB2

PALB2, or PAL for short, is our new friend. She's a newly discovered breast cancer gene who hangs out closest to our old friend BRCA2, or B2. She also hangs with B1 but not as much. But what does PAL do? According to some new research:"Overall, the researchers found, a PALB2 mutation carrier had a 35 percent chance of developing cancer by age 70. By comparison, women with BRCA1 mutations have a 50 to 70 percent chance of developing breast cancer by that age, and those with BRCA2 have a 40 to 60 percent chance...""The breast cancer risk for women younger than 40 with PALB2 mutation was eight to nine times higher than that of the general population. The risk was six to eight times higher among women ages 40 to 60 with these mutations, and five times as high among women older than 60... "The data also indicated that women with the PALB2 mutations were slightly more likely to have “triple-negative” breast cancer — a form resistant to hormone treatment, more aggressive, and more likely to recur than other subtypes...."A caution was added:"“This has to be tailored to the patients, who may have other mutations and varying family risk,” she said. “With no family history, the increase they found is 35 percent. If you have two or more family members with cancer, they found a risk of 58 percent.”"So PAL may be our friend but we don't want her to hang out with our family as well.  You can learn more about...
Source: Caroline's Breast Cancer Blog - Category: Cancer Tags: breast cancer cancer research cancer risk genetics Source Type: blogs

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In conclusion, drinking GT may have a positive effect on reducing BC risk, especially in long-term, high doses. PMID: 31959020 [PubMed - as supplied by publisher]
Source: International Journal of Food Sciences and Nutrition - Category: Nutrition Tags: Int J Food Sci Nutr Source Type: research
Publication date: Available online 22 January 2020Source: Chemico-Biological InteractionsAuthor(s): Yaqiu Wang, Can Liu, Zhihui Xie, Hong LuAbstractTripartite motif (TRIM) protein family is a group of proteins, which belongs to RING family of ubiquitin E3 ligases. TRIM proteins are involved in oncogenesis, while the roles in different cancers are controversial. However, the expression pattern and biological functions of TRIM47 in breast cancer remain unclear. In the present study, we aimed to investigate the function of TRIM47 in the progression and metastasis of breast cancer. TRIM47 was found to be significantly up-regul...
Source: Chemico Biological Interactions - Category: Biochemistry Source Type: research
New J. Chem., 2020, Advance Article DOI: 10.1039/C9NJ04961D, PaperElavarasan Nagaraj, Prakash Shanmugam, Kokila Karuppannan, Thirunavukkarasu Chinnasamy, Sujatha Venugopal ZnO/GO nanocomposites were synthesized and their antibacterial activities assessed against various pathogens. They are potential antibacterial materials and significant anticancer activity against the MCF-7 breast cancer cell line compared to the A549 lung cancer cell line. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - Category: Chemistry Authors: Source Type: research
I am currently in my senior year of undergrad, and i honestly don't know what my chances of getting into a mid-tier medical school is since my scores are kinda low average. I personally feel i am a little different because im ADHD and Dyslexic and coupled with my experience as a whole. Currently, i have a 3.4 overall GPA scored a 505 on the MCAT The second author on Triple-negative Metaplastic Breast Cancer research paper. I work full time as a Regional Representative for a hemp company... WAMC since i am a not a normal case?
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: What Are My Chances? WAMC Medical Source Type: forums
Authors: Wang X, Wen Y, Xue L, Lu R, Tang H, Gao N, Zhang J, Xue Q PMID: 31961109 [PubMed - as supplied by publisher]
Source: Panminerva Medica - Category: General Medicine Tags: Panminerva Med Source Type: research
Authors: Wang P, Xue L, Wang L, Tang H, Lv C, Xue Q PMID: 31961108 [PubMed - as supplied by publisher]
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ConclusionsXJR played an important role in anti-BC through multi-component, multi-target and multi-pathway mechanisms, in which quercetin and ursolic acid may be the key active components. The anticancer effect of multi-component application was better than that of a single component. This study not only deepened our understanding of the role of TCM in the prevention and treatment of diseases, but also provided a reference for the in-depth research, development and application of the ancient medicine.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
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Source: Anti-Cancer Agents in Medicinal Chemistry - Category: Cancer & Oncology Authors: Tags: Research article Source Type: research
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