Dispelling the Myths of Insulin Therapy

By Betsy Carlisle In my position as a pharmacist and certified diabetes educator, physicians often assign me the task of starting their patients with Type 2 diabetes on insulin therapy. Unfortunately, in most situations, insulin has been presented to these patients as a last-ditch treatment option, after target glucose goals have not been achieved or maintained with lifestyle modifications and other therapies. Not surprisingly, I encounter people who are upset at the news that insulin is now necessary. Others feel anxious or overwhelmed by the prospect of fitting insulin into their lifestyles. Many people believe that insulin causes the complications of diabetes. Here is some information to dispel some of these myths about insulin therapy: Myth 1: "It's my fault I am being put on insulin because I didn't do what I was supposed to do." People with diabetes often view the switch to insulin therapy as sign of personal failure in managing their diabetes. Insulin may be perceived as a punishment for failing to exercise, eat properly, or take their medicines. However, due to the progressive nature of Type 2 diabetes, people should expect to eventually require insulin therapy — this is due to the diabetes running its natural course, not to failure on their part. It is inevitable that the insulin-producing beta cells of the pancreas will deteriorate over time, resulting in insulin deficiency. In other words, the pancreas cannot keep up with the body's need for insul...
Source: Diabetes Self-Management - Category: Diabetes Authors: Source Type: blogs

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The Diabetes Empowerment Summit is a free virtual conference taking place May 1-5, 2019, that offers many mental health resources for coping with diabetes.
Source: Diabetes Mine - Category: Endocrinology Authors: Source Type: blogs
These authors from Hungary highlight that no studies to date have employed the EuroQol EQ-5D questionnaire to assess health-related quality of life (HRQoL) in patients with pemphigus. Their aim with this study was to evaluate the HRQoL of patients with pemphigus by the EQ-5D and to analyse the convergent and known-groups validity of the EQ-5D in this patient population. To do this they carried out a multicentre cross-sectional study between 2014 and 2017. Their outcome measures included the five-level EQ-5D, Dermatology Life Quality Index, Autoimmune Bullous Skin Disorder Intensity Score and an average pain-intensity visua...
Source: Journal of Investigative Dermatology - Category: Dermatology Tags: Editorial Source Type: research
Aging and cellular senescence are known contributors to the pathophysiology of diabetic nonhealing wounds. However, the dynamic interplay of senescent cells in diabetic wounds is not well understood. Wilkinson et  al. show that macrophages, which constitute a large portion of accumulated senescent cells, release a senescence-associated secretory profile (SASP) that is rich in CXCR2 ligands, which drive fibroblasts toward a profibrotic and senescent phenotype. A selective CXCR2 antagonist promoted healing of diabetic wounds, showing a new avenue for potential therapeutic developments.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Commentary Source Type: research
In this study, we firstly investigated the effect of genetic background for isolating of AFSCs from chemical defined medium. We found that AFSCs could be generated from blastocysts of pure Sv129 strain mice, ICR strain mice and hybrid mice; except pure C57BL/6 and non-obese diabetic (NOD). In the second, using Act A and BMP4, the AFSCs were able to convert to trophoblast stem cells like stem cells (TSLSCs) which contributed to both ICM and trophectoderm (TE), as well as extraembryonic tissues in chimera. Due to the culture conditions applied to derive EpiSCs were essentially the same as those used for propagating human plu...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
We describe a novel approach for bilateral lung transplantation as off-pump technique via median sternotomy which has the potential to combine the advantages of median sternotomy with less postoperative pain and better chest wall function and off-pump technique with reduced risk of primary graft dysfunction and bleeding complications.
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
CONCLUSION: Psoriatic patients were at higher risk of metabolic disorders. LCN2 was not related to metabolic disturbances in our patients. NBUVB might exert its therapeutic effect in psoriasis through reduction of tissue LCN2. PMID: 30995143 [PubMed - as supplied by publisher]
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research
ConclusionOs vesalianum is a rare cause of lateral midfoot pain. The differential diagnosis must include an acute fracture, non-union, apophysitis, peroneus brevis tendon lesion and lateral plantar fasciopathy.
Source: Fuss and Sprunggelenk - Category: Podiatry Source Type: research
“Treat the patient, not the number.” This is a very old and sound medical school teaching. However, when it comes to blood sugar control in diabetes, we have tended to treat the number, thinking that a lower number would equal better health. Uncontrolled type 2 diabetes (also known as adult-onset diabetes) is associated with all sorts of very bad things: infections, angry nerve endings causing chronic pain, damaged kidneys, vision loss and blindness, blocked arteries causing heart attacks, strokes, and amputations… So of course, it made good sense that the lower the blood sugar, the lower the chances of ...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Diabetes Health Source Type: blogs
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Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Diabetes is an adamant condition requiring constant attention. Let me show you how technology can take the burden off the shoulders of suffering patients and their loved ones. One in eleven persons has to cope with diabetes worldwide on a daily basis  According to the latest estimates of the WHO, 422 million people suffer from diabetes worldwide – and the number is growing steadily. It means that one person in eleven has to manage the chronic condition on a daily basis, which might lead to stroke, blindness, heart attack, kidney failure or amputation. There are two types of diabetes: when the body doe...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Empowered Patients Future of Medicine Health Sensors & Trackers chronic diabetes disease gc2 gc3 management technology Source Type: blogs
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