Targeted and global pharmacometabolomics in everolimus-based immunosuppression: association of co-medication and lysophosphatidylcholines with dose requirement

ConclusionFor the first time, this study describes distinct ERL metabolite patterns in heart transplant patients and detected potentially new drug –drug interactions. The global metabolic profiling facilitated the discovery of novel metabolites associated with ERL dose requirement that might represent new clinically valuable biomarkers to guide ERL therapy.
Source: Metabolomics - Category: Biology Source Type: research