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Lateralization effects on functional connectivity of the auditory network in patients with unilateral pulsatile tinnitus as detected by functional MRI

In this study, we recruited 23 left-sided, 23 right-sided PT (LSPT, RSPT) patients and 23 normal controls (NC). We combined applied independent component analysis and seed-based functional connectivity (FC) analysis to investigate alteration feature of the FC of the AN by using resting-state functional magnetic resonance imaging (rs-fMRI). Compared with NC, LSPT patients demonstrated disconnected FC within the AN on both sides. Disrupted network integrity between AN and several brain functional networks, including executive control network, self-perceptual network and the limbic network, was also demonstrated in LSPT patient group bilaterally. In contrast, compared with NC, RSPT demonstrated decreased FC within the AN on the left side, but significant increased FC within the AN on the right side (symptomatic side). Enhanced FC between AN and executive control network, self-perceptual network and limbic network was also found mainly on the right side in patients with RSPT. Positive FC between the auditory network and the limbic network may be a reason to explain why RSPT patients are willing to be in the clinic. Briefly, LSPT exhibit disrupted network integrity in brain functional networks. But RSPT is featured by enhanced FC within AN and between networks, especially on the right (symptomatic) side. Corroboration of featured FC helps to reveal the pathophysiological changing process of the brain in patients with PT, providing imaging-based biomarker to distinguish PT from oth...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - Category: Psychiatry Source Type: research

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Conclusion: The ELH was progressive in the long-term course of the disease in this large population of definite MD patients, but short-term and middle-term fluctuations of the symptom severity did not involve measurable variations of the ELH. Furthermore, the symptom severity did not decrease with increasing disease duration.
Source: Otology and Neurotology - Category: ENT & OMF Tags: Vestibular Disorders Source Type: research
Conclusions: The associations between auditory-related networks are weakened in tinnitus patients, even if they have normal hearing. It is possible that rs-fMRI can be a tool for objective examination of tinnitus, by focusing the auditory-related areas.
Source: Otology and Neurotology - Category: ENT & OMF Tags: Audiology Source Type: research
In conclusion, taVNS at acupoints CO10-12, TF4 could activate the prefrontal, auditory and limbic cortices of healthy brain and this scheme could be a promising tool for tinnitus treatment. PMID: 29305037 [PubMed - as supplied by publisher]
Source: Hearing Research - Category: Audiology Authors: Tags: Hear Res Source Type: research
Authors: Kleinjung T, Thüring C, Güntensperger D, Neff P, Meyer M Abstract Neurofeedback is a noninvasive neuromodulation technique employing real-time display of brain activity in terms of electroencephalography (EEG) signals to teach self-regulation of distinct patterns of brain activity or influence brain activity in a targeted manner. The benefit of this approach for control of symptoms in attention deficit disorders, hyperactivity, depression, and migraine has been proven. Studies in recent years have also repeatedly shown this treatment to improve tinnitus symptoms, although it has not become e...
Source: HNO - Category: ENT & OMF Tags: HNO Source Type: research
Conclusion Due to the direct link between poor executive functions and prefrontal cortex alterations in TP, we postulate that a lack of inhibitory modulation following an impaired top-down cognitive control may maintain tinnitus by hampering habituation mechanisms. This deficit in executive functions caused by prefrontal cortex alterations would be a key-factor in the generation and persistence of tinnitus.
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
Abstract Noninvasive brain stimulation can modify phantom sounds for longer periods by modulating neural activity and putatively inducing regional neuroplastic changes. However, treatment response is limited and there are no good demographic or clinical predictors for treatment outcome. We used state‐of‐the‐art voxel‐based morphometry (VBM) to investigate whether transcranial magnetic stimulation‐induced neuroplasticity determines therapeutic outcome. Sixty subjects chronically experiencing phantom sounds (i.e., tinnitus) received repetitive transcranial magnetic stimulation (rTMS) of left dorsolateral prefrontal...
Source: Human Brain Mapping - Category: Neurology Authors: Tags: Research Article Source Type: research
CONCLUSION: In our series, QOL is not influenced in patients with unilateral untreated small VS in comparison to Germany's general population. This is helpful information when advising patients during follow-up and finding out the optimal timing of individual treatment. PMID: 29048255 [PubMed - as supplied by publisher]
Source: Neurological Research - Category: Neurology Tags: Neurol Res Source Type: research
Publication date: February 2018 Source:Biomedical Signal Processing and Control, Volume 40 Author(s): Burhan Ergen, Murat Baykara, Cahit Polat This experimental study aimed to investigate a relationship between tinnitus and thicknesses of internal auditory canal and nerves in it. It was performed on brain magnetic resonance images of patients who consulted the ear, nose, and throat clinic with tinnitus complaint. Statistical hypothesis tests and classification experiments were performed on these data to find out structural differences in internal auditory channel components in patients with tinnitus after obtaining cross-...
Source: Biomedical Signal Processing and Control - Category: Biomedical Science Source Type: research
Conclusion: MRI showed that a high percentage of ears affected by Menière's disease or delayed endolymphatic hydrops had EH. Further studies should evaluate the implications of EH in ears, especially in those with sudden SNHL, in terms of secondary or pre-existing EH.
Source: Otology and Neurotology - Category: ENT & OMF Tags: Sensorineural Hearing Loss and Tinnitus Source Type: research
Conclusion: Historically, HRCT has been the imaging modality of choice for diagnosing LVA. Although a higher concordance rate of HRT2-MRI was found compared with previous studies utilizing earlier MRI technology, HRCT still detected a larger number of patients with clinically significant hearing loss compared with MRI. Given the high concordance rate and efficacy of both modalities in diagnosing LVA, the ultimate decision of which modality to choose may depend on other patient-specific and clinical factors.
Source: Otology and Neurotology - Category: ENT & OMF Tags: Sensorineural Hearing Loss and Tinnitus Source Type: research
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