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Kidney disease drug recommended by Nice 'may do more harm than good'

Exclusive: Little evidence that phosphate binders improve patient wellbeing, warn experts, while one type may contribute to increased risk of cardiovascular diseaseThe UK ’s drug guidelines body is recommending a type of medication to treat chronic kidney disease despite no firm evidence that it benefits patients – and some signs that the drugs may do more harm than good, experts have warned.Phosphate binders are commonly prescribed to lower blood phosphate levels in patients with advanced kidney disease, including those on dialysis. High phosphate has been linked to worse patient outcomes, including bone and muscle problems, a build-up of calcium in the blood vessels causing them to stiffen, and an increased death rate.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Drugs The National Institute for Health and Care Excellence (Nice) NHS Society Science Source Type: news

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FRIDAY, Feb. 23, 2018 -- Chronic kidney disease may affect brain function in children and teens, especially those on dialysis, researchers say. Results of their study review suggest academic assistance may be needed in specific areas, including...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
There is a large and growing burden of diabetes globally. In 2013, 382 million people had diabetes and this number has been projected to increase to 592 million by 2035 [1]. With increasing life expectancy and prevalence of type 2 diabetes, complications and deaths attributable to diabetes will also increase, especially if there is no concomitant improvement in the health system for its early management [1]. Chronic kidney disease (CKD) is a common complication in people with type 2 diabetes [2] and may in some cases progress to end-stage renal disease, which requires dialysis and/or kidney transplant which are associated ...
Source: Primary Care Diabetes - Category: Primary Care Authors: Tags: Original research Source Type: research
Authors: Li JX, Yu GQ, Zhuang YZ Abstract OBJECTIVE: To investigate the impact of serum FGF23 levels on blood pressure of patients with chronic kidney disease (CKD). PATIENTS AND METHODS: 128 patients with chronic kidney disease were selected from February 2013 to January 2016. Using CKD staging method, all the patients were divided into 1 to 5 stages according to the glomerular filtration rate. Enzyme-Linked ImmunoSorbent Assay (ELISA) was used to detect serum FGF23 levels of CKD patients and healthy control subjects. 24 h blood pressure monitoring method was used to monitor the mean arterial pressure of patie...
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Conclusion: In contrast to some existing literature, this study has demonstrated that EPO resistance and iron deficiency contributes to anemia in CKD and serum ferritin can be used to assess the iron level of dialysis naïve CKD patients at every stage of the disease.
Source: Nigerian Journal of Clinical Practice - Category: Rural Health Authors: Source Type: research
The objective of this study was to explore associations between polymorphisms in the feline CaSR (fCaSR) and biochemical changes observed in CKD-MBD. Client owned cats (≥9years) were retrospectively included. SNP discovery was performed in 20 cats with azotaemic CKD and normal or dysregulated calcium concentrations. Non-pedigree cats (n=192) (125 with azotaemic CKD and 66 healthy), Persians (n=40) and Burmese (n=25) were genotyped for all identified SNPs using KASP. Biochemical parameters from the date of CKD diagnosis or from first visit to the clinic (healthy cats) were used. Associations between genotype and ionized ...
Source: The Veterinary Journal - Category: Veterinary Research Source Type: research
Condition:   Anemia; Hemodialysis Dependent Chronic Kidney Disease Interventions:   Drug: MT-6548;   Drug: Darbepoetin alfa;   Drug: MT-6548-matching placebo;   Drug: Darbepoetin alfa-matching placebo Sponsor:   Mitsubishi Tanabe Pharma Corporation Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
In Aotearoa/New Zealand, M āori, as the indigenous people, experience chronic kidney disease at three times the rate of non-Māori, non-Pacific New Zealanders. Māori commence dialysis treatment for end-stage kid...
Source: International Journal for Equity in Health - Category: International Medicine & Public Health Authors: Tags: Research Source Type: research
Abstract Description: The Kidney Disease: Improving Global Outcomes (KDIGO) 2017 Clinical Practice Guideline Update for the Diagnosis, Evaluation, Prevention, and Treatment of Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD) is a selective update of the prior CKD-MBD guideline published in 2009. The guideline update and the original publication are intended to assist practitioners caring for adults with CKD and those receiving long-term dialysis. Methods: Development of the guideline update followed an explicit process of evidence review and appraisal. The approach adopted by the Work Group and the ...
Source: Annals of Internal Medicine - Category: Internal Medicine Authors: Tags: Ann Intern Med Source Type: research
Discussion: The finding that previous CVD was positively associated with eLVH may result from the permanent high cardiac output and the strong tendency for aortic valve calcification in this group of long‐term hemodialysis patients, who suffer generally also from chronic anemia and various other metabolic derangements. No association was found between eLVH and parameters of fluid balance. The distribution of left ventricular geometry did not alter over time. The assumption that LV geometry worsens over time in susceptible individuals, who then suffer from a high risk of dying, may explain these findings.
Source: Hemodialysis International - Category: Hematology Authors: Tags: Original Article Source Type: research
Abstract Chronic Kidney Disease affects approximately 10% of the world's adult population: it is within the top 20 causes of death worldwide, and its impact on patients and their families can be devastating. World Kidney Day and International Women's Day in 2018 coincide, thus offering an opportunity to reflect on the importance of women's health and specifically their kidney health, on the community, and the next generations, as well as to strive to be more curious about the unique aspects of kidney disease in women so that we may apply those learnings more broadly. Girls and women, who make up approximately 50% ...
Source: Journal of Nephrology - Category: Urology & Nephrology Authors: Tags: J Nephrol Source Type: research
More News: Calcium | Cardiology | Cardiovascular | Chronic Kidney Disease | Dialysis | Heart | National Institute for Health and Clinical Excelle | Science | Urology & Nephrology