Kidney disease drug recommended by Nice 'may do more harm than good'

Exclusive: Little evidence that phosphate binders improve patient wellbeing, warn experts, while one type may contribute to increased risk of cardiovascular diseaseThe UK ’s drug guidelines body is recommending a type of medication to treat chronic kidney disease despite no firm evidence that it benefits patients – and some signs that the drugs may do more harm than good, experts have warned.Phosphate binders are commonly prescribed to lower blood phosphate levels in patients with advanced kidney disease, including those on dialysis. High phosphate has been linked to worse patient outcomes, including bone and muscle problems, a build-up of calcium in the blood vessels causing them to stiffen, and an increased death rate.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Drugs The National Institute for Health and Care Excellence (Nice) NHS Society Science Source Type: news

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Authors: Li C, Yap DYH, Chan G, Wen YB, Li H, Tang C, Li XM, Li XW, Chan TM Abstract OBJECTIVE: Renal thrombotic microangiopathy (TMA) is an uncommon pathological finding in lupus nephritis (LN), and its clinical significance remains to be defined. METHODS: 24 patients with lupus nephritis (LN) and renal TMA were selected from a retrospective review of 677 biopsy-proven LN patients, and compared with 48 LN Controls without TMA (in 1:2 ratio) matched according to demographics and treatments. RESULTS: Renal TMA was noted in 3.5% of kidney biopsies of LN. TMA was associated with a higher prevalence of anti-Ro ...
Source: Journal of Rheumatology - Category: Rheumatology Tags: J Rheumatol Source Type: research
This study aims at identifying the obstacles faced by young individuals on peritoneal dialysis treatment, as well as to examine the coping strategies they use in renal care. A qualitative study was carried out from a critical-interpretative approach. Participants were 12 young people with kidney failure, under peritoneal dialysis treatment, who lived in Guadalajara, Mexico. Using a snowball sampling, seven men and five women were selected. The data was obtained through narrative interviews and participant observation, as well as conversations on WhatsApp and Facebook. Content analysis was conducted. In addition to informed...
Source: Saude e Sociedade - Category: International Medicine & Public Health Source Type: research
Authors: Sivakumar C, Jubb VM, Lamplugh A, Bhandari S Abstract Safety of parenteral iron therapy is critical and has been demonstrated in several studies, but concerns persist on safety. We performed a retrospective single-center study investigating the safety and efficacy of parenteral iron administration using 2 iron preparations-Monofer and Cosmofer (Pharmacosmos A/S, Holbaek, Denmark)-in patients with chronic kidney disease (CKD), on peritoneal dialysis (PD) and non-dialysis. A database of CKD patients receiving intravenous (IV) iron was analyzed. Side effects were recorded during infusion, post-infusion, and a...
Source: Peritoneal Dialysis International - Category: Urology & Nephrology Tags: Perit Dial Int Source Type: research
Patients with chronic kidney disease (CKD) have an increased risk of adverse cardiovascular/cerebrovascular events. The aim of this study is to clarify whether stress myocardial perfusion single-photon emission computed tomography (SPECT) could predict cardiovascular/cerebrovascular events. In the Gunma-CKD SPECT Study, a multicenter prospective cohort trial, 311 patients with CKD (estimated glomerular filtration rate #x3c; 60 min/mL/1.73 m2) including 50 patients on hemodialysis underwent stress99mTc-tetrofosmin SPECT for suspected ischemic heart disease and were followed for 2 years. The primary endpoint was the occurren...
Source: Cardiology - Category: Cardiology Source Type: research
[Guardian] No fewer than 25 million Nigerians are living with chronic kidney disease (CKD) with over 80 per cent of the patients on dialysis dying due to high cost of treatment.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
Kidney transplantation is the best treatment for patients with end-stage renal disease (ESRD) because of a significant survival benefit conferred compared to patients who remain on haemodialysis.1 Although the prevalence of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection in patients with ESRD has significantly declined over time, it remains at least 4-times higher than in the general population.2,3 Chronic HCV or HBV infection can result in chronic liver disease, cirrhosis, and hepatocellular carcinoma4 –6 and increase the risk of chronic kidney disease (CKD).
Source: Journal of Hepatology - Category: Gastroenterology Authors: Tags: Research Article Source Type: research
Publication date: January 2019Source: Advances in Chronic Kidney Disease, Volume 26, Issue 1Author(s): Snigdha Reddy, Chandrika Chitturi, Jerry YeeInfections after cardiovascular disease are the second most common cause of death in the chronic kidney disease population. Vaccination is an important component of maintaining health and wellness in patients with kidney disease. There is a changing epidemiologic landscape for several vaccine-preventable illnesses from childhood to adulthood and unfounded public perception of safety concerns. Several mechanisms have been proposed to cause inadequate vaccine protection in this hi...
Source: Advances in Chronic Kidney Disease - Category: Urology & Nephrology Source Type: research
Publication date: January 2019Source: Advances in Chronic Kidney Disease, Volume 26, Issue 1Author(s): A. Mary VilayInfections are an important cause of morbidity and mortality among patients with chronic kidney disease. Therefore, appropriate antibiotic dosing is imperative to achieve positive patient outcomes while minimizing antibiotic dose-related toxicity. Accurately assessing renal function and determining the influence of renal replacement therapy on antibiotic clearance makes drug dosing in this patient population challenging. Furthermore, as technological advances in hemodialysis and peritoneal dialysis occur, res...
Source: Advances in Chronic Kidney Disease - Category: Urology & Nephrology Source Type: research
Publication date: January 2019Source: Advances in Chronic Kidney Disease, Volume 26, Issue 1Author(s): Vivek Soi, Chantale Daifi, Jerry Yee, Elizabeth AdamsAn in-depth understanding of viral hepatitis is important to the care of patients with end-stage renal disease undergoing hemodialysis. Both hepatitis B and C viruses are acquired through hematogenous spread and can lead to horizontal transmission. Concurrent hepatic and renal injuries have ominous outcomes with significant morbidity. Hepatitis B incidence has decreased through practices including vaccination of nonimmune individuals and isolation of patients with the d...
Source: Advances in Chronic Kidney Disease - Category: Urology & Nephrology Source Type: research
Publication date: January 2019Source: Advances in Chronic Kidney Disease, Volume 26, Issue 1Author(s): Lizbeth J. Cahuayme-Zuniga, Karen B. BrustPatients with chronic kidney disease have impaired immunity that increases their risk of infection. Increased incidence of mycobacterial infections, in particular Mycobacterium tuberculosis, is described in patients undergoing hemodialysis and peritoneal dialysis as well as after kidney transplantation in low-prevalence and high-prevalence settings. Diagnosis of this infection can be challenging because of atypical presentations that may lead to treatment delay and, consequently, ...
Source: Advances in Chronic Kidney Disease - Category: Urology & Nephrology Source Type: research
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