Log in to search using one of your social media accounts:

 

Kidney disease drug recommended by Nice 'may do more harm than good'

Exclusive: Little evidence that phosphate binders improve patient wellbeing, warn experts, while one type may contribute to increased risk of cardiovascular diseaseThe UK ’s drug guidelines body is recommending a type of medication to treat chronic kidney disease despite no firm evidence that it benefits patients – and some signs that the drugs may do more harm than good, experts have warned.Phosphate binders are commonly prescribed to lower blood phosphate levels in patients with advanced kidney disease, including those on dialysis. High phosphate has been linked to worse patient outcomes, including bone and muscle problems, a build-up of calcium in the blood vessels causing them to stiffen, and an increased death rate.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Drugs The National Institute for Health and Care Excellence (Nice) NHS Society Science Source Type: news

Related Links:

Authors: Liu ZH, Yu XQ, Yang JW, Jiang AL, Liu BC, Xing CY, Lou JZ, Wang M, Cheng H, Liu J, Fu JZ, Zhang AH, Zhang M, Zhou QL, Yu C, Wang R, Wang L, Chen YQ, Guan TJ, Peng A, Nan C, Hao CM, Cheng XY, China Dialysis Calcification Study Group Abstract OBJECTIVE: With limited data available on calcification prevalence in chronic kidney disease (CKD) patients on dialysis, the China Dialysis Calcification Study (CDCS) determined the prevalence of vascular/valvular calcification (VC) and association of risk factors in Chinese patients with prevalent hemodialysis (HD) or peritoneal dialysis (PD). METHODS: CKD patients...
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research
ConclusionsControlled clinical trials are needed to determine which populations may profit from more frequent potassium-monitoring and subsequent interventions, e.g., change or withdrawal of potassium-influencing drugs, in order to restore normal values and prevent cardiovascular outcomes.Registration DetailsRegistration in PROSPERO (Centre for Reviews and Dissemination University of York, York, UK): CRD42016048897 (https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=48897).
Source: Cardiovascular Drugs and Therapy - Category: Cardiology Source Type: research
We thank Dr. Labriola and Dr. Jadoul for their comments.1 We fully agree with the relevance of falls as a major risk factor of fracture in such patients.2 Falls were mentioned and included in Figure  12 as an important determinant of fractures. However, this issue was not extensively discussed because of few relevant data available in chronic kidney disease (CKD) patients. CKD patients, including those treated by dialysis, may have a high propensity for falls. Several factors are probably invo lved, including accelerated aging with deleterious consequences such as impaired cognitive function, neurological disorders, v...
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Letter to the Editor Source Type: research
A 44-year-old male patient presented with recurrent urinary tract infections (urine cultures negative) for 2 years. He was diagnosed as having a urethral stricture, and he underwent dilatations. However, his renal functions deteriorated, and he developed chronic kidney disease (CKD) requiring dialysis and transplantation. Pretransplant workup revealed 4 –5 leukocytes on urine examination, proteinuria (0.2 g/d), and a serum creatinine level of 6.7 mg/dl. Magnetic resonance imaging of his kidneys showed multifocal hyperintense lesions in both.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Nephrology Image Source Type: research
We thank Fusaro and her colleagues for their comments.1 We concur that there is a sound need for large, well-designed clinical studies to assess the prevalence, risk factors, treatment, and outcome of vertebral fractures in patients with chronic kidney disease (CKD). In our review,2 we did not include quantitative vertebral morphology as assessed by MorphoXpress software to quantify vertebral fractures in CKD. The assessment of vertebral fractures by quantitative vertebral morphology in patients on dialysis and renal transplant recipients resulted in the validation of the tool in osteoporotic patients of the general popula...
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Letter to the Editor Source Type: research
Authors: Haroon S, Davenport A Abstract INTRODUCTION: Only a minority of patients with chronic kidney disease treated by hemodialysis are currently treated at home. Until relatively recently, the only type of hemodialysis machine available for these patients was a slightly smaller version of the standard machines used for in-center dialysis treatments. Areas covered: There are now an alternative generation of dialysis machines specifically designed for home hemodialysis. The home dialysis patient wants a smaller machine, which is intuitive to use, easy to trouble shoot, robust and reliable, quick to set-up and put ...
Source: Expert Review of Medical Devices - Category: Medical Devices Tags: Expert Rev Med Devices Source Type: research
AbstractBackgroundChronic kidney disease (CKD) is very common now and is associated with high overall and cardiovascular mortality. Numerous studies have reported that abdominal obesity is a risk factor for cardiovascular mortality. We investigated the link between sagittal abdominal diameter (SAD) and Framingham risk score in non-dialysis CKD patients.MethodsIn a cross-sectional study, we enrolled 307 prevalent non-dialysis CKD patients (175 males, aged 50.7  ± 17.04 years). SAD and Framingham risk score were measured.ResultsFramingham cardiovascular disease risk score was independently predicted by SAD (P 
Source: International Urology and Nephrology - Category: Urology & Nephrology Source Type: research
AbstractPurposeTo examine the characteristics of the midstream urine microbiome in adults with stage 3 –5 non-dialysis-dependent chronic kidney disease (CKD).MethodsPatients with non-dialysis-dependent CKD (estimated glomerular filtration rate [eGFR]    50% reads) by the generaCorynebacterium (n = 11),Staphylococcus (n = 9),Streptococcus (n = 7),Lactobacillus (n = 7),Gardnerella (n = 7),Prevotella (n = 4),Escherichia_Shigella (n = 3), andEnterobacteriaceae (n = 2); the rest lacked a dominant g...
Source: International Urology and Nephrology - Category: Urology & Nephrology Source Type: research
Innovative Kidney Care Company works with Health Systems and Payers to enable value-based care for CKD and ESRD populations VIENNA, Va., April 11, 2018 -- (Healthcare Sales &Marketing Network) -- Somatus, an innovative care delivery and management com... Devices, Venture Capital Somatus, Chronic Kidney Disease, End Stage Renal Disease, dialysis
Source: HSMN NewsFeed - Category: Pharmaceuticals Source Type: news
AbstractIntroductionTeneligliptin is a novel oral dipeptidyl peptidase-4 inhibitor for the treatment of type 2 diabetes mellitus (T2DM). Safety and efficacy of teneligliptin have been demonstrated in clinical studies; however, data supporting its use in patients with moderate or severe renal impairment are limited. This interim analysis of a post-marketing surveillance of teneligliptin, exploRing the long-term efficacy and safety included cardiovascUlar events in patients with type 2 diaBetes treated bY teneligliptin in the real-world (RUBY), aims to verify the long-term safety and efficacy of teneligliptin in Japanese pat...
Source: Diabetes Therapy - Category: Endocrinology Source Type: research
More News: Calcium | Cardiology | Cardiovascular | Chronic Kidney Disease | Dialysis | Heart | National Institute for Health and Clinical Excelle | Science | Urology & Nephrology