RNA N6 ‐methyladenosine methyltransferase METTL3 promotes liver cancer progression through YTHDF2 dependent post‐transcriptional silencing of SOCS2

In conclusion, we demonstrated that METTL3 was frequently up‐regulated in human HCC and contributed to HCC progression. METTL3 repressed SOCS2 expression in HCC via the m6A‐YTHDF2 dependent mechanism. Thus, our findings suggested a new dimension of epigenetic alteration in liver carcinogenesis. This article is protected by copyright. All rights reserved.

Source: Hepatology - November 24, 2017 Category: Internal Medicine Authors: Mengnuo Chen, Lai Wei, Cheuk ‐Ting Law, Felice Ho‐Ching Tsang, Jialing Shen, Carol Lai‐ Hung Cheng, Long‐Hin Tsang, Daniel Wai‐Hung Ho, David Kung‐Chun Chiu, Joyce Man‐Fong Lee, Carmen Chak‐Lui Wong, Irene Oi‐Lin Ng, Chun‐Ming Wong Tags: Hepatobiliary Malignancies Source Type: research