MRCZ - A file format for cryo-TEM data with fast compression

Publication date: Available online 23 November 2017 Source:Journal of Structural Biology Author(s): Robert A. McLeod, Ricardo Diogo Righetto, Andy Stewart, Henning Stahlberg The introduction of fast CMOS detectors is moving the field of transmission electron microscopy into the computer science field of big data. Automated data pipelines control the instrument and initial processing steps which imposes more onerous data transfer and archiving requirements. Here we conduct a technical demonstration whereby storage and read/write times are improved 10x at a dose rate of 1 e-/pix/frame for data from a Gatan K2 direct-detection device by combination of integer decimation and lossless compression. The example project is hosted at github.com/em-MRCZ and released under the BSD license.
Source: Journal of Structural Biology - Category: Biology Source Type: research
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