Protocol for the international lung screen trial (ilst): a cohort study to define ldct screening selection criteria and validate the pancan nodule management algorithm

Source: Respirology - Category: Respiratory Medicine Tags: Lung Cancer 2 Source Type: research

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Authors: Xu H, Dong L, Bin Z, Yansong H, Shaofeng L, Chang L, Chen C, Changli W Abstract Despite the excellent efficacy and low toxicity of photoresponse therapy, which has attracted considerable attention for use in non-small cell lung cancer (NSCLC) therapy, unsatisfactory cellular permeability, and instability, both in vitro and in vivo have limited further clinical applications of indole cyanine photosensitizers. Here, we explore the supramolecular self-assembly of a 'hyalurosome' that is mediated by calcium phosphate nanonuclei. Through hyaluronate-mediated CD44 targeting, the constructed hyalurosome...
Source: Drug Delivery - Category: Drugs & Pharmacology Tags: Drug Deliv Source Type: research
Source: Cancer Management and Research - Category: Cancer & Oncology Tags: Cancer Management and Research Source Type: research
ConclusionsIn summary, we identified TRIAP1 as a key contributor to the radioresistance of NSCLC by maintaining redox homeostasis.
Source: Thoracic Cancer - Category: Cancer & Oncology Authors: Tags: ORIGINAL ARTICLE Source Type: research
ConclusionsORR and PFS were significantly better in ILD patients than in irAEs ‐non‐ILD and non‐irAEs patients. Pre‐existing history of IP was an independent risk factor for ILD‐induced ICIs.
Source: Thoracic Cancer - Category: Cancer & Oncology Authors: Tags: ORIGINAL ARTICLE Source Type: research
ConclusionPORT remarkably reduced local recurrence and improved OS in stage III ‐pN2 NSCLC, especially in the multiple‐station pN2 group.
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
Authors: Hakozaki T, Kitazono M, Takamori M, Kiriu T Abstract Histologic transformation has been described as an acquired mechanism of resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs). We herein report the case of a woman with stage IV lung adenocarcinoma harboring EGFR exon 19 deletions who was initially treated with EGFR-TKIs; several cytotoxic chemotherapeutic regimens were used when resistance developed. A lymph node re-biopsy revealed histologic transformation of the tumor to combined small-cell lung cancer (SCLC) and squamous cell carcinoma (SCC) with retained EGFR exon ...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Source: OncoTargets and Therapy - Category: Cancer & Oncology Tags: OncoTargets and Therapy Source Type: research
CONCLUSION: These data collectively suggest that the expression of hsa-let-7g inhibits lung cancer cells apoptosis and promotes proliferation by down-regulating HOXB1. The results from this study demonstrate the potential of hsa-let-7g/HOXB1 axis as a therapeutic target for the treatment of lung cancer. PMID: 32102121 [PubMed - as supplied by publisher]
Source: Yonsei Medical Journal - Category: Universities & Medical Training Authors: Tags: Yonsei Med J Source Type: research
Many individuals, especially Blacks, at high risk of lung cancer are not eligible for screening by U.S. Preventive Services Task Force (USPSTF) guidelines, according to a new study.Reuters Health Information
Source: Medscape Pathology Headlines - Category: Pathology Tags: Hematology-Oncology News Source Type: news
THURSDAY, Feb. 27, 2020 -- Of those people in 10 states meeting the U.S. Preventive Services Task Force (USPSTF) recommendations for low-dose lung cancer screening, only 12.5 percent reported having had a screening exam in the past year, according...
Source: - Pharma News - Category: Pharmaceuticals Source Type: news
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