Induced pluripotent stem cells prevent endothelial cell leakage via timp ‐1 to reduce fak/snail pathway in sepsis‐induced acute lung injury

Source: Respirology - Category: Respiratory Medicine Tags: Critical Care Medicine Source Type: research

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Conclusions3D printed stem cells seem to have extensive applications in regenerative medicine for the treatment of various diseases. These cells help seed decellularisation of complete organs for regenerative medicine. This technology also applies to the reconstruction of heart valves and has excellent potential in valvular disease. These cells have higher capabilities to fulfil different medical requirements, but it is challenging to steer its growth as per the need of human kind. Scientists created 3D printed stem cells structure which can grow, and they have performed tissue regeneration experiments on them. Traditional...
Source: Clinical Epidemiology and Global Health - Category: Epidemiology Source Type: research
More than two dozen studies are under way or planned to test everything from traditional Chinese medicine to vitamin C, stem cells, steroids, and to medications developed to fight other viruses, like the flu and HIV.
Source: WebMD Health - Category: Consumer Health News Source Type: news
Conditions:   2019 Novel Coronavirus Pneumonia;   COVID-19 Interventions:   Biological: UC-MSCs;   Drug: Placebo Sponsors:   Wuhan Union Hospital, China;   Wuhan Hamilton Bio-technology Co., Ltd, China. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
This article describes the studies that have been conducted to date and emphasises that mortality after stem cell transplant (not attributed to CMV end-organ disease) has recently become the first proven indirect effect of CMV now that letermovir has significantly reduced non-relapse deaths.The implications for CMV vaccines are then discussed. Vaccines are already predicted to be highly cost-effective if they can reduce CMV end-organ disease. Health planners should now consider that cost effectiveness is likely to be enhanced further through reduction of the indirect effects of CMV. A prototype scheme for assessing this po...
Source: Antiviral Therapy - Category: Virology Source Type: research
Hepatocellular carcinoma represents one of the most aggressive cancers with high recurrence rates. The high recurrence is a major problem in the management of this disease. Cancer stem cells (CSCs) are often regarded as the basis of cancer recurrence. The anti-proliferative therapy kills the proliferating cells but induces mitotic quiescence in CSCs which remain as residual dormant CSCs. Later on, withdrawal of treatment reactivates the residual CSCs from dormancy to produce new cancer cells. The proliferation of these newly formed cancer cells initiates new tumor formation in the liver leading to tumor recurrence. HCC cel...
Source: Oncology Reviews - Category: Cancer & Oncology Source Type: research
Hematopoietic stem cell (HSC) attrition is considered the key event underlying progressive BM failure (BMF) in Fanconi anemia (FA), the most frequent inherited BMF disorder in humans. However, despite major advances, how the cellular, biochemical, and molecular alterations reported in FA lead to HSC exhaustion remains poorly understood. Here, we demonstrated in human and mouse cells that loss-of-function of FANCA or FANCC, products of 2 genes affecting more than 80% of FA patients worldwide, is associated with constitutive expression of the transcription factor microphthalmia (MiTF) through the cooperative, unscheduled act...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
The study is evaluating daratumumab plus lenalidomide, bortezomib, and dexamethasone in autologous stem cell transplant eligible patients newly diagnosed with multiple myeloma.
Source: CancerNetwork - Category: Cancer & Oncology Authors: Source Type: news
(Rice University) Rice University neurodevelopmental biologist Rosa Uribe has won a prestigious CAREER Award from the National Science Foundation to study neural crest cells, specialist stem cells that form the enteric nervous system and also cause neuroblastoma, the third most prevalent form of pediatric cancer in the U.S.
Source: EurekAlert! - Biology - Category: Biology Source Type: news
Transplantation of skeletal myoblast sheets is a promising strategy for the treatment of heart failure, and its therapeutic effects have already been proven in both animal disease models and clinical trials. M...
Source: Stem Cell Research and Therapy - Category: Stem Cells Authors: Tags: Research Source Type: research
Angiogenesis plays an important role in tissue repair and regeneration, and conditioned medium (CM) derived from mesenchymal stem cells (MSC-CM) possesses pro-angiogenesis. Nevertheless, the profile and concen...
Source: Stem Cell Research and Therapy - Category: Stem Cells Authors: Tags: Research Source Type: research
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