Development of an in ‐vitro mucus model to evaluate the effect of magnesium on current mucolytic therapies for cystic fibrosis treatment

Source: Respirology - Category: Respiratory Medicine Tags: Clinical Allergy & Immunology / Paediatric Lung Disease Source Type: research

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Chronic rhinosinusitis (CRS) is present in up to 100% of patients with cystic fibrosis (CF). CF-associated CRS is particularly recalcitrant, and sinus disease can have important implications in the health of the lower airways and overall quality of life in these patients. Both medical and surgical management play important roles in treating CF-associated CRS, but guidelines are lacking. This review summarizes the current literature on both medical and surgical management of this disease to provide an up-to-date analysis and recommendations on the treatment of CF-associated CRS.
Source: Immunology and Allergy Clinics of North America - Category: Allergy & Immunology Authors: Source Type: research
The objectives of this study were to: (1) compare otolaryngologists ’ and pulmonlogists’ understanding of long‐term chronic rhinosinusitis (CRS) management; and (2) query patient perceptions of otolaryngologic care and CRS.MethodsA cross ‐sectional survey was administered by the Cystic Fibrosis Foundation in 2018 to patients with CF or their caregivers, otolaryngologists, and pulmonologists. Statistical analysis was performed comparing specialists. Descriptive statistics were computed for patient/caregiver‐reported data.ResultsRespondents included 126 otolaryngologists, 115 pulmonologists, and 186 patient...
Source: International Forum of Allergy and Rhinology - Category: Allergy & Immunology Authors: Tags: ORIGINAL ARTICLE Source Type: research
ConclusionL. lactis suppressed the growth of 1 patientP. aeruginosa isolate and induced growth of another (a mucoid strain) in in vitro co ‐culture setting in the presence of mucin. Further experiments are required to assess the underlying interactions betweenL. lactis andP. aeruginosa.
Source: International Forum of Allergy and Rhinology - Category: Allergy & Immunology Authors: Tags: ORIGINAL ARTICLE Source Type: research
Cystic fibrosis (CF) is characterized by inflammation, progressive lung disease, and respiratory failure. Although the relationship is not well understood, patients with CF are thought to have a higher prevale...
Source: Allergy, Asthma and Clinical Immunology - Category: Allergy & Immunology Authors: Tags: Case report Source Type: research
ConclusionTo our knowledge, this is the first study to assess risk factors associated with neo ‐osteogenesis and patients with CF CRS. Interestingly, male gender was the only significant predictor of neo‐osteogenesis.
Source: International Forum of Allergy and Rhinology - Category: Allergy & Immunology Authors: Tags: ORIGINAL ARTICLE Source Type: research
ConclusionCF patients with pulmonary exacerbations have worse SNOT ‐22 and CFQ‐R 14+ scores than CF patients at their baseline health. This finding suggests a temporal relationship between sinonasal and pulmonary quality of life, and that worsening of both is associated with reduced pulmonary function.
Source: International Forum of Allergy and Rhinology - Category: Allergy & Immunology Authors: Tags: ORIGINAL ARTICLE Source Type: research
CONCLUSION: Our results did not show that S. aureus found in nasal mucosa membrane is significantly different in patients with or without NP. However, association of the presence of S. aureus in patients with nasal polyposis with asthma, allergy and inflammation has been shown. PMID: 31785225 [PubMed - as supplied by publisher]
Source: Neuroendocrinology Letters - Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research
Pediatric Allergy, Immunology, and Pulmonology,Volume 32, Issue 4, Page 149-154, December 2019.
Source: Pediatric, Allergy, Immunology, and Pulmonology - Category: Respiratory Medicine Authors: Source Type: research
Usually B is perceived as a purely neutrophilic disease. However, eosinophilic type of inflammation is observed in pts with B in clinical practice. The aim of the study was to determine the correlation between blood eosinophils level and sensitization to Aspergillus fumigatus (AF).Methods: The study included cohort of pts with confirmed by HRCT B. Peripheral blood eosinophils were counted in stable phase. Total serum IgE was evaluated by using conventional electrochemiluminescence immunoassay (ECLIA) and specific IgE to AF was measured by immunoCAP technology. The methods of descriptive statistics and non-parametric statis...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Allergy and immunology Source Type: research
In this study, OVA-sensitized/challenged mice were treated with AZM after inoculation with RSV. We found that AZM treatment not only suppressed AHR, but also reduced all key markers of exacerbation. Furthermore, TNFa-produced by alveolar macrophages was reduced with AZM treatment. Recombinant TNFa administration could reverse exacerbation in the presence of AZM. Our findings highlight the mechanism of AZM suppressed AHR and airway inflammation in RSV-induced asthma exacerbation through targeting the innate immune response linked to alveolar macrophages and TNFa production.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Allergy and immunology Source Type: research
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