Performance of different sets of single ‐nucleotide polymorphisms (snp) for typing mycobacterium tuberculosis(mtb) strains lineage and modern/ancient beijing sublineage

Source: Respirology - Category: Respiratory Medicine Tags: Tuberculosis 2 Source Type: research

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Conclusion: HIV patients with the disseminated TB have higher risk for ocular TB. As ocular symptoms are rare, still all of them need a detailed ocular examination to look for active ocular TB which will reclassify isolated pulmonary/extrapulmonary to disseminated TB warranting a detailed systemic examination. PMID: 32083986 [PubMed - as supplied by publisher]
Source: Ocular Immunology and Inflammation - Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research
Authors: De Smet D, Payen MC, Remes J, Van den Wijngaert S, Vouche M, Konopnicki D PMID: 32081503 [PubMed - as supplied by publisher]
Source: Medecine et Maladies Infectieuses - Category: Infectious Diseases Tags: Med Mal Infect Source Type: research
Publication date: Available online 27 January 2020Source: Current Medicine Research and PracticeAuthor(s): K.K. Chopra, Shweta SinghAbstractTuberculosis (TB) has remained a disease of public health importance since ages, affecting more than 10 million people globally and taking lives of 2 million people worldwide every year. Despite the dramatic improvements made in providing high-quality TB diagnostic services, since the discovery of the causative bacilli, many people with TB remain undiagnosed or get diagnosed only after long delays. Ten countries account for 77% of this gap and use only smear microscopy for diagnosis, w...
Source: Current Medicine Research and Practice - Category: General Medicine Source Type: research
Publication date: Available online 21 February 2020Source: Microbes and InfectionAuthor(s): Patrick Howlett, Elsa Du Bruyn, Hazel Morrison, Isiguzo C. Godsent, Katalin A. Wilkinson, Mpiko Ntsekhe, Robert J. WilkinsonAbstractTuberculous pericarditis is a severe form of extrapulmonary tuberculosis and is the commonest cause of pericardial effusion in high incidence settings. Mortality ranges between 8-34%, and it is the leading cause of pericardial constriction in Africa and Asia. Current understanding of the disease is based on models derived from studies performed in the 1940-50s. This review summarises recent advances in ...
Source: Microbes and Infection - Category: Infectious Diseases Source Type: research
Publication date: April 2020Source: Cancer Epidemiology, Volume 65Author(s): Faezeh Salamat, Mahmoud Khandashpour, Mohammad Naeimi-Tabiei, Ali Ariannia, Mohammad Ashaari, SeyedMehdi Sedaghat, Fatemeh Ghasemi-Kebria, Fatemeh Salamat, Abbas Moghaddami, Susan Hasanpour-Heidari, Reza Hoseinpour, Nastaran Jafari-Delouei, Hamid Ghayoriardahaei, Masoomeh Gholami, Abdolreza Fazel, Gholamreza Roshandel, Jacques Ferlay, Elisabete WeiderpassAbstractIntroductionWe aimed to present the time trends and geographical distribution of lung cancer in Golestan province, a high-risk area for pulmonary tuberculosis (TB) in Northern Iran (2004-2...
Source: Cancer Epidemiology - Category: Cancer & Oncology Source Type: research
Publication date: 20 February 2020Source: Cell, Volume 180, Issue 4Author(s): Jonathan M. Stokes, Kevin Yang, Kyle Swanson, Wengong Jin, Andres Cubillos-Ruiz, Nina M. Donghia, Craig R. MacNair, Shawn French, Lindsey A. Carfrae, Zohar Bloom-Ackerman, Victoria M. Tran, Anush Chiappino-Pepe, Ahmed H. Badran, Ian W. Andrews, Emma J. Chory, George M. Church, Eric D. Brown, Tommi S. Jaakkola, Regina Barzilay, James J. CollinsSummaryDue to the rapid emergence of antibiotic-resistant bacteria, there is a growing need to discover new antibiotics. To address this challenge, we trained a deep neural network capable of predicting mole...
Source: Cell - Category: Cytology Source Type: research
ConclusionOur novel rabbit LAM-specific mAbs performed well at recognizing LAM from slow-growing pathogenic mycobacteria, supporting their future diagnostic potential.
Source: Journal of Microbiology, Immunology and Infection - Category: Microbiology Source Type: research
Multidrug resistant tuberculosis (MDR-TB) remains a serious public health problem with poor treatment outcomes. Predictors of poor outcomes vary in different regions. Vietnam is among the top 30 high burden of...
Source: BMC Infectious Diseases - Category: Infectious Diseases Authors: Tags: Research article Source Type: research
It is estimated that one fourth of world population is infected with M. tuberculosis (Mtb) 1-5 and that only the 5-10 % of Mtb-infected individuals will progress to tuberculosis (TB) disease during life time.2,5 In 2017, 1 million (9%) of the worldwide TB cases were related to HIV-infected persons leading to 300,000 deaths.5 HIV-infection is responsible of an increased risk of progression to active disease, representing one of the main cause for active-TB disease, even in the absence of a deep CD4 T-cell impairment and even if under antiretroviral therapy (ART).
Source: Journal of Infection - Category: Infectious Diseases Authors: Tags: Original article Source Type: research
Today, interferon-gamma release assays (IGRAs) are essential tools for detecting infection with Mycobacterium tuberculosis (M. tuberculosis), including for diagnosing latent tuberculosis infection (LTBI). IGRAs, including both QuantiFERON (QFT) and T-SPOT.TB, enable direct observation of the response of a patient's blood cells to specific antigens derived from M. tuberculosis.1,2 On the other hand, IGRAs were not useful for accurately discriminating between active tuberculosis (active TB) and LTBI.
Source: Journal of Infection - Category: Infectious Diseases Authors: Source Type: research
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