Bronchiolitis obliterans syndrome is associated with increased p ‐glycoprotein expression and loss of glucocorticoid receptor from steroid resistant pro‐inflammatory cd8+t cells

Source: Respirology - Category: Respiratory Medicine Tags: Cell and Molecular Biology Source Type: research

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Kirolos A, Manti S, Blacow R, Tse G, Wilson T, Lister M, et al. A Systematic Review of Clinical Practice Guidelines for the Diagnosis and Management of Bronchiolitis. J Infect Dis 2019; jiz240.
Source: The Journal of Pediatrics - Category: Pediatrics Authors: Tags: Current Best Evidence Source Type: research
Authors: Pukai G, Duke T Abstract Background: Acute lower respiratory tract infections are the commonest cause of hospitalisation in young children and supportive care remains the cornerstone of management. A randomised open trial was undertaken at the Port Moresby General Hospital Children's Emergency Department (CED) to determine whether nebulised normal saline had beneficial effects.Methods: Children
Source: Paediatrics and international child health - Category: Pediatrics Tags: Paediatr Int Child Health Source Type: research
Mucosal Immunology, Published online: 17 February 2020; doi:10.1038/s41385-020-0268-8Long-lived regulatory T cells generated during severe bronchiolitis in infancy influence later progression to asthma
Source: Mucosal Immunology - Category: Allergy & Immunology Authors: Source Type: research
We describe the first case of HTLV associated bronchiolitis to be associated with HTLV-1c subtype infection. An Aboriginal man with HTLV-1 infection was repeatedly admitted to Alice Springs Hospital, central Australia, with hypercapnic respiratory failure from the age of 28 years. High resolution CT chest findings were consistent with bronchiolitis and large numbers of lymphocytes were found in bronchoalveolar lavage fluid (BALF). After extensive investigations failed to find a cause, he was tested for HTLV-1 and found to have a high HTLV-1c proviral load (6.8%) in peripheral blood leukocytes and in BALF (4.7%). The admini...
Source: IDCases - Category: Infectious Diseases Source Type: research
Condition:   Bronchiolitis Intervention:   Procedure: Chest physiotherapy Sponsor:   Universidade do Porto Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
González V Abstract OBJECTIVE: The aims of our study are to evaluate the effectiveness and security of CPAP (continuous positive airway pressure) in infants transferred with acute respiratory failure (ARF) and to compare their evolution in PICU between CPAP vs oxygen therapy. MATERIALS AND METHODS: We conducted a retrospective observational and analytical study by reviewing the health records of infants with ARF aged 0 to 12months that required interhospital transfer to the PICU. RESULTS: We included 110 patients: 71 transported with CPAP and 39 with oxygen therapy. The main cause of ARF was acute...
Source: Anales de Pediatria - Category: Pediatrics Authors: Tags: An Pediatr (Barc) Source Type: research
This study also demonstrates that HRV infection upregulates PAD2 protein expression, and increases levels of protein citrullination, including histone H3, in human bronchial epithelial cells. Increased PADI gene expression and HDP citrullination during infection may represent a novel viral evasion mechanism, likely applicable to a wide range of pathogens, and should therefore be considered in the design of therapeutic peptide derivatives.
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Publication date: Available online 1 February 2020Source: Journal of Emergency NursingAuthor(s): Elyssa B. Wood, Scott Barnett, Gina Harrison, Kristina Presgrave, Sarah Stinson, Erin RovelliAbstractIntroductionAlthough evidence supports the addition of video discharge instructions to improve caregiver knowledge among English-speaking caregivers of children in the pediatric emergency department, there is no evidence about the effectiveness of videos for Spanish-speaking caregivers. The purpose of this study was to test whether Spanish video discharge instructions added to standard written and oral discharge instructions wou...
Source: Journal of Emergency Nursing - Category: Nursing Source Type: research
This article reviews the available literature on the field of RSV disease severity and discusses important factors associated to susceptibility and different disease outcome.Expert opinion: The severity of RSV-induced illness is a phenomenon that depends on a variety of graded mechanisms of interaction between the host, virus, and environment. This may lead to differences in intensity of immune response in the lung and different courses of the disease. By characterizing, classifying and grading the affecting factors in high-risk patients versus those who do not fall ill by RSV, we may find therapies or point to disease-lim...
Source: Expert Review of Respiratory Medicine - Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research
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