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Mechanisms underlying the heterogeneity of myelodysplastic syndromes

• In myelodysplastic syndromes, the disease-initiating cell is a rare hematopoietic stem cell which transmits the genetic abnormalities to its myeloid and lymphoid progeny.• The heterogeneity of MDS phenotypes is related to the diversity of genetic, the various combinations and order of mutation s in cooperating genes, and the variegation of clonal hematopoietic hierarchy.• A mutation in granulo-monocytic progenitor may the transformation into acute myeloid leukemia.
Source: Experimental Hematology - Category: Hematology Authors: Tags: Review Source Type: research

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