Child ’s science experiment solves chronic disease mystery

“Chew this.” I was instructed. “But don’t swallow. Just tell me when IT happens.” IT? What was IT? I’d have to find out. My researcher’s son — who enlisted me in his science experiment — wasn’t telling. So I obliged and started chewing. It tasted just as I expected at first. Bland. Almost cardboard-like. And then the strangest thing occurred. After about a minute, a hint of sweetness tickled my tongue. I kept chewing. A few seconds later, it intensified… like I was sucking on candy. And a few seconds after that it felt like I had an entire spoonful of sugar in my mouth. What happened? Like a shredder rips paper into little strips… my teeth and enzymes in my saliva broke down the complex molecules in the food. In a nutshell, simply chewing the food longer revealed what was REALLY inside the food. Now, the food I was asked to chew was what many people would consider harmless. Some would even call it healthy. A cracker. But as you’ve just seen, essentially it was no different than eating sugar. That’s right… the complex carbohydrates found in starchy foods like rice, pasta, and bread quickly turn into simple carbohydrates that have the same effect on your body as sugar. Which means they have the same harmful health effects on your body that sugar does. But so what? How much sugar can be in a cracker? A lot more than you would think. Just three measly crackers break down into the equivale...
Source: Al Sears, MD Natural Remedies - Category: Complementary Medicine Authors: Tags: Nutrition Weight Loss carbohydrates carbs disease sugar Syndrome Zero Source Type: news

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Publication date: Available online 12 October 2018Source: Life SciencesAuthor(s): Li-chun Zhang, Yu Wang, Wei Liu, Xue-min Zhang, Miao Fan, Min ZhaoAbstractAimsTo study the protective effects and mechanisms of human umbilical cord mesenchymal stem cells (hUCMSCs) and overexpression of antioxidant gene SOD2 on lung injury by establishing a rat model of paraquat (PQ)-induced lung injury.Main methodsThe hUCMSCs cell line overexpressed SOD2 was established. After intraperitoneal injection of PQ solution (24 mg/kg) 3 h later, the different groups of hUCMSCs cell lines were injected through the tail veins of rats. Bronchoalv...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 11 October 2018Source: Pharmacological ResearchAuthor(s): Sara R. Martins-Neves, Anne-Marie Cleton-Jansen, Célia M.F. GomesAbstractThe development of local recurrence and metastatic disease most probably attributable to the intrinsic or acquired resistance of tumor cells to standard therapy, still constitute the major clinical problem preventing the cure of cancer patients. Despite progress in the research of new therapeutic targets and compounds, resistant cells displaying stem-like properties seem to play a leading role in therapeutic failures and to be the culprit cells responsi...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
Authors: Martin-Pena A, Porter RM, Plumton G, McCarrel TM, Morton AJ, Guijarro MV, Ghivizzani SC, Sharma B, Palmer GD Abstract Successful clinical translation of mesenchymal stem cell (MSC)-based therapies for cartilage repair will likely require the implementation of standardised protocols and broadly applicable tools to facilitate the comparisons among cell types and chondroinduction methods. The present study investigated the utility of recombinant lentiviral reporter vectors as reliable tools for comparing chondrogenic potential among primary cell populations and distinguishing cellular-level variations of chon...
Source: European Cells and Materials - Category: Cytology Tags: Eur Cell Mater Source Type: research
Abstract T cell factor, the effector transcription factor of the WNT signaling pathway, was so named because of the primary observation that it is indispensable for T cell development in the thymus. Since this discovery, the role of this signaling pathway has been extensively studied in T cell development, hematopoiesis, and stem cells; however, its functional role in mature T cells has remained relatively underinvestigated. Over the last few years, various studies have demonstrated that T cell factor can directly influence T cell function and the differentiation of Th1, Th2, Th17, regulatory T cell, follicular he...
Source: Journal of Immunology - Category: Allergy & Immunology Authors: Tags: J Immunol Source Type: research
In this study, we report the human induced pluripotent stem cell line (iPSC) HSAN5-T203 M-iPSC, generated from human dermal fibroblasts (HDF) of a woman carrying a heterozygous c.608C > T mutation in the nerve growth factor gene potentially associated with hereditary sensory and autonomic neuropathy type 5 (HSAN5). HDF were reprogrammed using transient expression of key transcription factors for pluripotency and immune evasion via transfection of synthetic mRNA and miRNA. HSAN5-T203 M-iPSC retained the disease-associated genotype c.608C > T, while maintaining a normal karyotype, showed robust and abundant...
Source: Stem Cell Research - Category: Stem Cells Source Type: research
Publication date: Available online 12 October 2018Source: Stem Cell ResearchAuthor(s): Rashmi Tandon, Björn Brändl, Natalya Baryshnikova, Alexandro Landshammer, Laura Steenpaß, Oliver Keminer, Ole Pless, Franz-Josef MüllerAbstractTwo isogenic hiPSC lines, ZIPi013-B and ZIPi013-E, were generated by reprogramming fetal dermal fibroblasts with episomal vectors. Previously, the same fetal fibroblasts were reprogrammed multiple times in a study comparing other reprogramming methods. As a consequence, the genomes have been sequenced multiple times. Both new cell lines offer the opportunity to study basic ste...
Source: Stem Cell Research - Category: Stem Cells Source Type: research
Authors: Litwinowicz R, Kapelak B, Sadowski J, Kędziora A, Bartus K Abstract Ischemic heart disease is a major cause of death and disabilities worldwide. Unfortunately, not all patients are suitable for direct revascularization. Cell-based therapies may be alternative options because of their potential to promote neovascularisation and endothelial repair, improving myocardial perfusion. The success of cell-based therapies depends on the type of implanted stem cells, delivery method and underlying disease. Several different cell populations including bone marrow-derived mononuclear cells (MNCs), mesenchymal stromal ce...
Source: Polish Journal of Cardio-Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Tags: Kardiochir Torakochirurgia Pol Source Type: research
ConclusionsSubchondral autologous bone marrow concentrate was an effective procedure for treating young patients with knee osteoarthritis following secondary ON of the knee related to corticosteroids with a lower complication rate and a quicker recovery as compared with TKA.
Source: International Orthopaedics - Category: Orthopaedics Source Type: research
Publication date: Available online 12 October 2018Source: NeuroscienceAuthor(s): Shan Wang, Longjian Huang, Yong Zhang, Yuchen Peng, Xiaoliang Wang, Ying PengAbstractIt has been reported that oxidative stress could result in damage to the developing brain. L-3-n-butylphthalide (L-NBP) could inhibit neuronal cell apoptosis and has neurogenesis effect in different animal and cellular models. However, whether L-NBP could protect the process of neurogenesis in neural stem cells (NSCs) against oxidative stress injury is still unclear. Here, in the present study, we evaluated the neuroprotective effect of L-NBP in NSCs against H...
Source: Neuroscience - Category: Neuroscience Source Type: research
AbstractPurpose of ReviewNovel immunotherapies such as checkpoint inhibitors, bispecific antibodies, and chimeric antigen receptor T cells are leading to promising responses when treating solid tumors and hematological malignancies. T cell neoplasms include leukemia and lymphomas that are derived from T cells and overall are characterized by poor clinical outcomes. This review describes the rational and preliminary results of immunotherapy for patients with T cell lymphoma and leukemia.Recent FindingsFor T cell neoplasms, despite significant research effort, only few agents, such as monoclonal antibodies and allogeneic ste...
Source: Current Hematologic Malignancy Reports - Category: Hematology Source Type: research
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