Personalized nanomedicine for CNS diseases.

Personalized nanomedicine for CNS diseases.
Drug Discov Today. 2017 Nov 15;:
Authors: Kaushik A, Jayant RD, Bhardwaj V, Nair M
Abstract
Central nervous system (CNS) diseases are rapidly increasing globally. Currently used therapeutic agents to treat CNS diseases exhibit significant efficacy. However, the inability of these drugs to cross the blood-brain barrier (BBB) and invasiveness of the technologies to achieve localized drug delivery in disease-specific parts of the brain have thwarted pain-free and complete treatment of CNS diseases. Therefore, the safe, non-invasive, and targeted delivery of drugs to the brain using nanoparticles (NPs) is currently receiving considerable research attention. Here, we highlight advances in state-of-the-art personalized nanomedicine for the treatment of CNS diseases (with a focus on dementia), the related challenges, possible solutions, and prospects for nano-enabled personalized medicine.
PMID: 29155026 [PubMed - as supplied by publisher]

Source: Drug Discovery Today - November 15, 2017 Category: Drugs & Pharmacology Authors: Kaushik A, Jayant RD, Bhardwaj V, Nair M Tags: Drug Discov Today Source Type: research