Eosinophil persistence in  vivo and sustained viability ex vivo in response to respiratory challenge with fungal allergens

Conclusion and Clinical RelevanceEosinophils are phenotypically and functionally heterogeneous. As shown here, eosinophils from fungal allergen–challenged wild‐type mice maintain a distinct cytokine profile, and, unlike eosinophils isolated from IL5tg mice, they survive ex vivo in the absence of exogenous pro‐survival cytokine support. As treatments for asthma currently in development focus on limiting eosinophil viability via strategic cytokine blockade, the molecular mechanisms underlying differential survival merit further investigation.

Source: Clinical and Experimental Allergy - November 22, 2017 Category: Allergy & Immunology Authors: W. E. Geslewitz, C. M. Percopo, H. F. Rosenberg Tags: ORIGINAL ARTICLE Source Type: research