The immunogenetics of Neurological Disease.
This article is protected by copyright. All rights reserved. PMID: 29159928 [PubMed - as supplied by publisher]
DISCUSSION: These findings may allow improved tracer-independent amyloid quantitation. PMID: 30006100 [PubMed - as supplied by publisher]
Authors: Huang A, Amos TB, Joshi K, Wang L, Nash A Abstract BACKGROUND: Schizophrenia is a serious public health problem that affects ∼1% of the US population. AIMS: To examine treatment patterns and evaluate healthcare resource utilization and costs among young adults (18-35 years) with schizophrenia who were early in the disease. MATERIALS AND METHODS: Patients aged 18-64 years with ≥2 schizophrenia diagnoses in the identification period (01JAN2012-30SEPT2015) and continuous enrollment for ≥12 months pre- and post-index date were identified from the OptumInsight Clinformatics DataMart. Demograph...
In conclusion, WISKET rats showed disturbances in the pupillary light reflex, suggesting a general shift of autonomic balance towards a sympathetic predominance. The results provide further evidence to support the validity of WISKET rats as a complex, chronic animal model of schizophrenia. PMID: 30005738 [PubMed - in process]
Authors: Jacob JE, Cherian A, Gopakumar K, Iype T, Yohannan DG, Divya KP Abstract Chaotic analysis is a relatively novel area in the study of physiological signals. Chaotic features of electroencephalogram have been analyzed in various disease states like epilepsy, Alzheimer's disease, sleep disorders, and depression. All these diseases have primary involvement of the brain. Our study examines the chaotic parameters in metabolic encephalopathy, where the brain functions are involved secondary to a metabolic disturbance. Our analysis clearly showed significant lower values for chaotic parameters, correlation dimensi...
New research offers 'the first population evidence for a causal link' between herpes infection and the development of Alzheimer's disease.
In this study we analyzed if Map was able to grow within astrocytes and investigated on the presence of antibodies against PtpA and PknG proteins in MS and NMOSD patients by ELISA. Map was unable to proliferate in astrocytes after of 72 h post-infection, but we observed a high level of antibodies against both virulence factors, suggesting that these patients have been exposed/infected with Map.
In this study, we investigated costimulatory molecules on B cells in the blood and in the thymus as well as by TLR9 and IL-21 stimulations in AChR+ MG patients with or without immunosuppressive treatment and controls.CD80 and CD86 expression on B cells was increased in the peripheral blood and in the thymus of untreated patients. CD86 was further amplified by IL-21.
This study investigated clinicians' use of dichotomous versus multi-point scales for rating these six domains.
Enhancement of social function is an important goal in the treatment of schizophrenia. To designate appropriate measures of real-world functioning, the Validation of Everyday Real-World Outcomes initiative recommended the Specific Levels of Functioning-Scale (SLOF). The SLOF has been developed as an interview-based assessment tool; the scores by clinicians are based on information from both patients and caregivers (Leifker et al., 2009). The SLOF covers interpersonal functioning, everyday activities, and vocational functioning (Schneider and Struening, 1983).
Eye movement abnormalities have been reported in schizophrenia; however, their influences on everyday life remain unknown. From data on 69 subjects with schizophrenia and 246 healthy subjects, we found positive correlations between eye movement measures and work hours, which were only significant in subjects with schizophrenia. This relationship was also confirmed in a multi-site dataset including 118 subjects with schizophrenia and 280 healthy subjects. These findings further strengthen our understanding of eye movement abnormalities and their relevance in clinical recovery.