Therapeutic Anticoagulation in Patients with Primary Brain Tumors or Secondary Brain Metastasis.
Therapeutic Anticoagulation in Patients with Primary Brain Tumors or Secondary Brain Metastasis. Oncologist. 2017 Nov 20;: Authors: Lin RJ, Green DL, Shah GL Abstract Patients with primary or metastatic brain tumors are at increased risk of developing venous thromboses. However, the potential benefit of therapeutic anticoagulation in these patients must be weighed against the deadly complication of intracranial hemorrhage. In this review, we summarize available evidence and recent studies of intracranial bleeding risks in primary and metastatic tumors and the impact of therapeutic anticoagulation. We find that for the majority of primary and treated metastatic brain tumors, the risk of spontaneous bleeding is acceptable and not further increased by careful therapeutic anticoagulation with low molecular weight heparin or direct oral anticoagulants, although thrombocytopenia (platelet count less than 50,000/μL) and other coagulopathies are relative contraindications. Patients with brain metastasis from melanoma, renal cell carcinoma, choriocarcinoma, thyroid carcinoma, and hepatocellular carcinoma have a higher tendency to bleed spontaneously than noted in patients with other malignancies, and thus warrant routine brain imaging and alternative strategies such as inferior vena cava filter placement in the acute setting of venous thromboembolism before consideration of therapeutic anticoagulation. IMPLICATIONS FOR PRACTICE: Malignant gliomas are asso...
Publication date: Available online 30 May 2020Source: Pathology - Research and PracticeAuthor(s): Wenjing Qi, Chang Shi, Pengxin Zhang, Lu Feng, Junying Wang, Dan Chen
Publication date: Available online 30 May 2020Source: Gynecologic Oncology ReportsAuthor(s): Anya Laibangyang, Raanan Alter, Yasmin Hasan, S. Diane Yamada
[Frequency and predictive factors of venous thrombosis in Behçet's disease]. Rev Med Interne. 2020 May 26;: Authors: Ha-Ou-Nou FZ, Essaadouni L Abstract OBJECTIVE: To investigate the clinical features of venous thrombosis in patients with Behçet's disease and to determine the patients at high risk for this complication. METHODS: We retrospectively studied patients with venous thrombosis (n = 157) who were followed up in the Internal Medicine department. These patients were divided into two groups according to the existence (n = 60, 38.2%) or not (n = 97, 61.8%) of Beh&cced...
Publication date: Available online 30 May 2020Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyAuthor(s): Kevin C. Lee, Sung-Kiang Chuang
Publication date: Available online 30 May 2020Source: Pharmacological ResearchAuthor(s): Ling Wang, Ke Deng, Liang Gong, Liang Zhou, Sapna Sayed, Huan Li, Qi Sun, Zijie Su, Zhongyuan Wang, Shanshan Liu, Huifang Zhu, Jiaxing Song, Desheng Lu
Publication date: Available online 30 May 2020Source: Pharmacological ResearchAuthor(s): Pedro Miguel Lacal, Maria Grazia Atzori, Federica Ruffini, Manuel Scimeca, Elena Bonanno, Rosella Cicconi, Maurizio Mattei, Roberta Bernardini, Stefania D’Atri, Lucio Tentori, Grazia Graziani
Publication date: Available online 31 May 2020Source: Pharmacology &TherapeuticsAuthor(s): Jie Yu, Bingling Zhong, Qingwen Xiao, Lida Du, Ying Hou, Hong-Shuo Sun, Jin-Jian Lu, Xiuping Chen
Publication date: Available online 31 May 2020Source: Pharmacology &TherapeuticsAuthor(s): Kevin M. Levine, Kai Ding, Lyuqin Chen, Steffi Oesterreich
Publication date: August 2020Source: Biomedicine &Pharmacotherapy, Volume 128Author(s): Fernanda Carrilho de Menezes, Laertty Garcia de Sousa Cabral, Maria Carla Petrellis, Cyro Festa Neto, Durvanei Augusto Maria
Publication date: August 2020Source: Biomedicine &Pharmacotherapy, Volume 128Author(s): Qi Chen, Huachao Xu, Jiang Zhu, Kehai Feng, Changlu Hu
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