Does sympathetic dysfunction occur before denervation in pure autonomic failure?

Conclusions: The finding of normal NET abundance in PAF suggests intact sympathetic nerves but with reduced NE synthesis. The finding of elevated plasma ratio of 3,4-DHPG: NE and reduced VMAT2 in PAF indicates a shift towards intraneuronal NE metabolism over sequestration in sympathetic nerves and suggests that sympathetic dysfunction may occur ahead of denervation.

Source: Clinical Science - November 21, 2017 Category: Biomedical Science Authors: Guo, L., Esler, M. D., Sari, C., Phillips, S., Lambert, E. A., Straznicky, N. E., Lambert, G. W., Corcoran, S. J. Tags: PublishAheadOfPrint Source Type: research