Identification of genes carrying rare variants of moderate to large effect in schizophrenia: A replication study

The discovery of copy number variants (CNVs) of moderate to high risk for schizophrenia opens the door to genetic counseling for families with segregating variants (Kirov, 2015), and justifies the search for additional rare variants of moderate to high risk, such as single nucleotide variants (SNVs). Pioneer work by Need et al. (2012) revealed the inexistence of low-frequency exonic variants with moderate risk; therefore, collapsing rare variants before the analysis emerged as an appropriate alternative.
Source: Schizophrenia Research - Category: Psychiatry Authors: Tags: Letter to the Editor Source Type: research