Methadone Treatment of Opiate Addiction: A Systematic Review of Comparative Studies

Conclusion and Recommendations More intervention-based clinical trials are needed to provide a strong alternative candidate therapy for management of opiate use disorder. Buprenorphine, although a promising candidate, should be researched more regarding treatment retention and patient satisfaction before any conclusions can be made regarding its standard use for opiate substitution maintenance treatment of pregnant patients with opiate use disorder. Heroin-assisted treatment still cannot be considered in opiate addicts refractory to MMT; more data should be collected regarding efficacy in larger participant populations under blinded conditions. Safety, generalizability, and diversion should be studied in further detail. Based on the present data, SROM is not a more effective alternative to methadone. Further clinical research with sound methodology is warranted to explore its potential use in this respect.   References Substance Abuse and Mental Health Services Administration, Center for Behavioral Health Statistics and Quality. (2015). Behavioral Health Trends in the United States: Results from the 2014 National Survey on Drug Use and Health. Rockville, MD: Substance Abuse and Mental Health Services Administration. Available at http://www.samhsa.gov/data/sites/default/files/NSDUH-FRR1-2014/NSDUH-FRR1-2014.pdf Centers for Disease Control and Prevention, National Center for Health Statistics, National Vital Statistics System, Mortality File. (2015). Number and Age-Adju...
Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Current Issue General Review buphernorphin heroin methadone opiate opiate addiction treatment withdrawal Source Type: research

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This study was done by collecting wild PU and cultivated PU and compared with a counterfeit which is commonly found in the market. Fourier Transform Infrared (FTIR) and Two-Dimension Infrared (2DIR) for the qualitative analysis are often regarded as green methods because the original resources of the test sample are preserved. The different spectral patterns of the counterfeit PU compared with the genuine PU were clearly indicated in 1D FTIR spectrum. The 2DIR spectrum of counterfeit PU showed more than 70% dissimilarity compared to genuine PU. This rapid and simple sample preparation enhances the speed of qualitative anal...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
Publication date: Available online 23 August 2019Source: Chinese Chemical LettersAuthor(s): Jian Li, Qi-Long Hu, Xue-Ping Chen, Ke-Qiang Hou, Albert S.C. Chan, Xiao-Feng XiongAbstractAn efficient asymmetric and enantio-swithchable organocatalytic [3+3] annulation reaction using MBH-2-naphthoates of nitroalkenes and 4-hydroxyquinolin-2(1H)-ones has been developed. Densely substituted tetrahydropyrano[3,2-c]quinolinones scaffolds with two adjacent stereogenic centers are obtained with high yield (up to 95% yield) and good stereoselectivities (up to>20:1 dr and 96% ee) in an enantio-switchable manner. Furthermore, gram sca...
Source: Chinese Chemical Letters - Category: Chemistry Source Type: research
Publication date: Available online 23 August 2019Source: Chinese Chemical LettersAuthor(s): Qiang Wang, Qingqing Chen, Guoyu Jiang, Mengting Xia, Mengjiao Wang, Yongdong Li, Xiaoming Ma, Jianguo Wang, Xinggui GuAbstractAn AIEgen decorated porphyrin (TPETPyP) was easily obtained through a one-step reaction. The bulky TPE in TPETPyP greatly impeded the intermolecular π-π stacking of the porphyrin core, which significantly suppressed aggregation-caused quenching (ACQ) effect of TPETPyP in aqueous solution. The four pyridinium salts formed in TPETPyP also render the whole molecule water solubility, which eliminated its a...
Source: Chinese Chemical Letters - Category: Chemistry Source Type: research
Publication date: Available online 23 August 2019Source: Chinese Chemical LettersAuthor(s): Yan Cai, Yang Wang, Chenwei Wang, Renhua Long, Leyu Cao, Yanmei Chen, Yong YaoAbstractHere we described the design and synthesis of a discrete 3D amphiphilic metallacage 4, in which the tetragonal prismatic frameworks act as the hydrophobic cores and the poly(ethylene glycol) (PEG) chains as the hydrophilic tails. The structure of 4 was characterized by 1H NMR, 31P NMR and electrospray ionization time-of-flight mass spectrometry (ESI-TOF-MS). Notably, 4 with its long PEG tails was subsequently ordered into micelles at a low concentr...
Source: Chinese Chemical Letters - Category: Chemistry Source Type: research
This study indicates a mutualistic-symbiotic relationship between augmented bacteria and soil microflora with enhanced detoxification of xenobiotics leading to a sustainable approach for restoration of contaminated lands.Graphical abstract
Source: Chemical Engineering Journal - Category: Chemistry Source Type: research
Publication date: 15 January 2020Source: Chemical Engineering Journal, Volume 380Author(s): Fan Li, Jun Duan, Shuting Tian, Haodong Ji, Yangmo Zhu, Zongsu Wei, Dongye ZhaoAbstractPer- and polyfluoroalkyl substances (PFAS) are a class of anthropogenic compounds comprised of a perfluoroalkyl backbone and a terminal functional group. As our knowledge on their environmental and health impacts grow, PFAS have drawn increasing regulatory attention and research interest in recent years. While long-chain PFAS have been the center of active research in the past decade or so, and while industrial production and applications of short...
Source: Chemical Engineering Journal - Category: Chemistry Source Type: research
Publication date: Available online 23 August 2019Source: Arabian Journal of ChemistryAuthor(s): Venkata Narayana Palakollu, Tirivashe E. Chiwunze, Chen Liu, Rajshekhar KarpoormathAbstractAcetaminophen (AC) is one of the most commonly prescribed analgesic and antipyretic drug, which is considered to be safe as well as effective. Rational use of AC does not pose any toxicity or adverse effects, however, an overdose or prolonged use could lead to nephrotoxicity and severe hepatoxicity. Thus, monitoring of AC is essential for drug safety. In this work, a facile Fe2O3/reduced graphene oxide (Fe2O3/RGO) nanocomposite was synthes...
Source: Arabian Journal of Chemistry - Category: Chemistry Source Type: research
Publication date: 24 August 2019Source: New Scientist, Volume 243, Issue 3244Author(s): Clare Wilson
Source: New Scientist - Category: Science Source Type: research
ConclusionsAmong women undergoing ART, pre-pregnancy maternal underweight was associated with lower birth weight, increased LBW and SGA risks, and decreased fetal macrosomia and LGA risks in singleton infants.
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research
Authors: Abstract Human trafficking, or modern-day slavery, is a global problem with broad reach that is often underrecognized in the United States. Victims of trafficking have been found in a wide range of legal and illegal business settings, and this frequently hidden population is most often exploited in the commercial sex industry, agriculture, factories, hotels, restaurants, as domestic workers, and by marriage brokers and some adoption firms. Human trafficking disproportionately affects underserved women and children, with more than 70% of trafficking cases involving women and girls and more than 90% of vic...
Source: Obstetrics and Gynecology - Category: OBGYN Tags: Obstet Gynecol Source Type: research
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