Reducing the Duration of Untreated Psychosis in the United States (R34 Clinical Trial Required)

Funding Opportunity PAR-18-232 from the NIH Guide for Grants and Contracts. Approximately 100,000 adolescents and young adults in the United States experience a first episode of psychosis (FEP) every year. The early phase of psychotic illness is widely viewed as a critical opportunity for indicated prevention, and a chance to alter the downward trajectory and poor outcomes associated with schizophrenia and related psychotic disorders. Compared to traditional treatment approaches, programs that integrate pharmacologic, psychological, and rehabilitation interventions for FEP, i.e., team-based Coordinated Specialty Care (CSC), have been found to produce a range of positive clinical and functional outcomes. However, the timing of treatment is critical; short and long-term outcomes are better when individuals begin treatment close to the onset of psychosis. Unfortunately, numerous studies find a substantial delay between the onset of psychotic symptoms and the initiation of FEP care; in the U.S. treatment is typically delayed between one and three years. Early identification of FEP, rapid referral to evidence-based services, and effective engagement in CSC are essential to shortening the duration of untreated psychosis (DUP) and pre-empting the functional deterioration common in psychotic disorders. The World Health Organization advocates reducing DUP to 3 months or less. Accordingly, this Funding Opportunity Announcement (FOA) seeks planning grant applications that (1) identify ...
Source: NIH Funding Opportunities (Notices, PA, RFA) - Category: Research Source Type: funding

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Publication date: Available online 18 June 2019Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Se Hyun Kim, Samuel S. Hwang, Hee Yeon Jung, Yeni Kim, Yong Min Ahn, In Won Chung, Yong Sik KimAbstractAuditory verbal hallucinations (AVHs) constitute a frequent and distressing symptom of schizophrenia, associated with physical, emotional, and cognitive challenges. Despite their clinical importance, changes in the multiple dimensions of AVHs during treatment have rarely been examined, and subjective views thereof have received minimal attention. Here, we evaluated 87 patients with schizophrenia-...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - Category: Psychiatry Source Type: research
Neuropsychopharmacology, Published online: 18 June 2019; doi:10.1038/s41386-019-0440-6Disconnection of drug-response and placebo-response in acute-phase antipsychotic drug trials on schizophrenia? Meta-regression analysis
Source: Neuropsychopharmacology - Category: Neurology Authors: Source Type: research
AbstractTo evaluate the course of neuropsychological impairment, patients with first-episode schizophrenia and healthy controls were assessed with a comprehensive test battery at the time of index treatment and after a 5- and 15-year follow-up period. Summary scores for verbal intelligence (VBI), spatial organization, verbal fluency, verbal learning, semantic memory, visual memory, delay/retention rate, short-term memory, visual –motor processing and attention (VSM) and abstraction/flexibility were constructed. Our results show that neurocognitive functioning is impaired already at the onset of schizophrenia and rema...
Source: European Archives of Psychiatry and Clinical Neuroscience - Category: Neuroscience Source Type: research
Disorders of the brain are not confined to this precious lump of fat that is typically thought to be shielded from rest of the body by the blood-brain barrier. Accumulating evidence now challenges Cartesian dualism by demonstrating that many brain disorders, including schizophrenia and depression, involve multiple systems (1). In this issue of Biological Psychiatry, Madrid-Gambin et  al. (2) report a case-control study nested in the Avon Longitudinal Study of Parents and Children (ALSPAC) birth cohort on the association of psychotic experiences (PEs) in young adults assessed around 18 years of age with blood lipidomic...
Source: Biological Psychiatry - Category: Psychiatry Authors: Tags: Commentary Source Type: research
Could an inexpensive, benign, and readily available intervention offer meaningful benefits for patients with serious mental illnesses (SMIs)? This question might be met with a reflexive skepticism among investigators in the field, for understandable reasons. Despite decades of research, standard drug therapies for schizophrenia and other SMIs remain inadequate, and simple remedies for such biologically complex disorders might seem implausible. Further, because our most ill patients often require some of the most toxic interventions in our arsenal (e.g., clozapine, lithium, or monoamine oxidase inhibitors), we may be condit...
Source: Biological Psychiatry - Category: Psychiatry Authors: Tags: Commentary Source Type: research
Analyzing two features of language use with machine learning could be a way to predict which individuals will later develop psychosis, study finds.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Schizophrenia Source Type: news
Kanye West’s interview about living with bipolar disorder has recently made the media rounds. Mr. West speaks about not liking medication, about mania being a creative outlet, and the career edge he believes he has because of living with mental illness. Suffice to say, whenever someone gains an audience by speaking about living with bipolar disorder, our hosts are going to take notice. Do they agree with Mr. West? Listen now to find out. SUBSCRIBE &REVIEW “Do you know many homeless schizophrenics who are eating well?” – Gabe Howard   Highlights From ‘Kanye West Bipolar’...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: A Bipolar, A Schizophrenic, and a Podcast Minding the Media Source Type: blogs
(Universit é de Gen è ve) Schizophrenia may be related to the deletion syndrome. However, not everyone who has the syndrome necessarily develops psychotic symptoms. What triggers the illness? Researchers (UNIGE) have provided an initial answer after analysing several years of patients with deletion syndrome. They found that the size of the hippocampus was smaller than normal but followed the same developmental curve as in healthy subjects. Yet, when the first psychotic symptoms appear - generally in adolescence - the hippocampus atrophies dramatically.
Source: EurekAlert! - Social and Behavioral Science - Category: International Medicine & Public Health Source Type: news
Publication date: Available online 15 June 2019Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Judit Cabana-Domínguez, Anu Shivalikanjli, Noèlia Fernàndez-Castillo, Bru CormandAbstractCocaine dependence is a complex psychiatric disorder that is highly comorbid with other psychiatric traits. Twin and adoption studies suggest that genetic variants contribute substantially to cocaine dependence susceptibility, which has an estimated heritability of 65–79%. Here we performed a meta-analysis of genome-wide association studies of cocaine dependence using four datasets f...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - Category: Psychiatry Source Type: research
Shared decision making (SDM) is often defined as an interactive process that ensures that both patient and practitioner are actively involved in the treatment and that they share all relevant information to ar...
Source: BMC Psychiatry - Category: Psychiatry Authors: Tags: Study protocol Source Type: research
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